ESTRO 2024 - Abstract Book

S1668

Clinical - Lung

ESTRO 2024

Conclusion:

Our initial study findings suggest that cardiac imaging holds clinical significance in evaluating patients with stage III lung cancer eligible for aggressive treatments. It can help identify cardiac risks even in clinically asymptomatic patients, potentially aiding in the prevention of adverse cardiac conditions.

Keywords: NSCLC; radiotherapy; cardiac imaging;

References:

Nardone V, Belfiore MP, De Chiara M, De Marco G, Patanè V, Balestrucci G, Buono M, Salvarezza M, Di Guida G, D'Angiolella D, Grassi R, D'Onofrio I, Cimmino G, Della Corte CM, Gambardella A, Morgillo F, Ciardiello F, Reginelli A, Cappabianca S. CARdioimaging in Lung Cancer PatiEnts Undergoing Radical RadioTherapy: CARE-RT Trial. Diagnostics (Basel). 2023 May 12;13(10):1717. doi: 10.3390/diagnostics13101717. PMID: 37238201; PMCID: PMC10217672.

1479

Digital Poster

Preliminary Results of a Bayesian Adaptive Radiotherapy Trial to Reduce Cardiac Toxicity in NSCLC

Ruitao Lin 1 , Xiaodong Zhang 2 , Tianlin Xu 3 , Ting Xu 4 , Rachel Maguire 4 , Kelsey Corrigan 4 , Efstratios Koutroumpakis 5 , Joe Chang 6 , Steven Lin 6 , Aileen Chen 6 , Quynh-Nhu Nguyen 6 , Saumil Gandhi 6 , Matthew Ning 6 , Julianna Bronk 4 , Stephen Chun 4 , Ali Ajdari 7 , Joshua Niedzielski 2 , Jinzhong Yang 2 , Xinru Chen 2 , Tinsu Pan 8 , Qing Meng 9 , Anne Tsao 6 , Radhe Mohan 2 , Anita Deswal 5 , Zhongxing Liao 6 1 The University of Texas MD Anderson Cancer Center, Department of Biostatistics, Houston, USA. 2 The University of Texas MD Anderson Cancer Center, Department of Radiation Physics, Houston, USA. 3 Edwards Lifesciences, Biostatistics, Irvine, USA. 4 The University of Texas MD Anderson Cancer Center, Department of Radiation Oncology, Houston, USA. 5 The University of Texas MD Anderson Cancer Center, Department of Cardiology, Houston, USA. 6 The University of Texas MD Anderson Cancer Center, Department of Thoracic-Head and Neck Medical Oncology, Houston, USA. 7 Harvard Medical School and Massachusetts General Hospital, Department of Radiation Oncology, Boston, USA. 8 The University of Texas MD Anderson Cancer Center, Department of Imaging Physics, Houston, USA. 9 The University of Texas MD Anderson Cancer Center, Department of Laboratory Medicine, Houston, USA

Purpose/Objective:

Radiation-induced heart disease is a significant concern in non-small cell lung cancer (NSCLC), which could lead to debilitating and even life-threatening cardiac conditions. [1-4] Current strategies focus on minimizing heart exposure, but individual susceptibility to cardiac toxicity varies. This prospective adaptive cohort registration study