ESTRO 2024 - Abstract Book

S1776

Clinical - Lung

ESTRO 2024

The average mean dose in the highest dose segments was 29.7Gy (EQD2). For longitudinal strain the normal values range from −15.9% to −22.1% [3]. The possible change in the highest dose segment equates to a worsening of 2.9%. For the longitudinal strain measured on echocardiogram, a worsening of 0.7%. The circumferential strain (normal range -20.9 to -27.8) equates to a worsening of 0.6%, and the radial strain (normal range 35.1 to 59) to a worsening of 0.8%

Conclusion:

In this small cohort of early stage NSCLC patients, no significant differences were found in cardiac condition before and after treatment. The dose versus change in cardiac strain before and after treatment varied between types of strains, and was <3% in the high dose segments.

Keywords: Cardiac toxicity, modelling

References:

[1] Standard-dose versus high-dose conformal radiotherapy with concurrent and consolidation carboplatin plus paclitaxel with or without cetuximab for patients with stage IIIA or IIIB non-small-cell lung cancer (RTOG 0617): a randomised, two-by-two factorial phase 3 study. J. Bradley et al., Lancet Oncol 2015; 16: 187 – 99 [2] Myocardial strain analysis by cardiac magnetic resonance 3D feature-tracking identifies subclinical abnormalities in patients with neuromuscular disease and no overt cardiac involvement. Azzu et al., European Heart Journal - Cardiovascular Imaging 2023; 24, 503-511