ESTRO 2024 - Abstract Book

S1914

Clinical - Mixed sites, palliation

ESTRO 2024

Keywords: cardiac, SABR, ventricular tachycardia

1349

Digital Poster

Dose Escalation in Bone and Spine Secondaries (DEBSS STUDY)

Dr.Kaviya lakshmi, Dr. kahnu charan Patro

mahatma gandhi cancer hospital and research institute, radiation oncology, vishakapatanam, India

Purpose/Objective:

Abstract

To compare and assess the pre and post radiotherapy pain control, early onset neurological and skeletal events using escalated dose schedules for vertebral (30Gy/5# or 25Gy/5#) and bone secondaries (30Gy/5#) in CT based planning.

Background

Currently the treatment options available for bones metastases include external beam radiotherapy, stereotactic body radiotherapy for spinal metastases, systemic therapy and systemic radio-nucleotides. This study aims to evaluate the pre and post treatment pain control using escalated dose for vertebral and bony metastasis

Material/Methods:

Methods:

In this study all patients with PET/MRI/BONE SCAN confirmed bone and spine secondaries fulfilling the inclusion and exclusion criteria is taken. Patients with vertebral metastases were assessed for spinal stability using Bilskey score. Patients with Bilskey score 0 and 1 received 30Gy in 5 fractions and patients with score more than or equal to 2 received 25Gy in 5 fractions. All oligo-metastatic bone disease received 30Gy in 5 fractions. Pain score was assessed using Universal Pain Assessment Tool and scores were given. Patients who have two scale reduction in the pain scale before and after radiotherapy and patients who were relieved from use of opioids are considered responders. All neurological deficits were also taken into account. CT based planning was carried out for all patients.

Results:

Over a period of 10 months (September 2022- June 2023),20patients,22 metastatic sites in total, who fulfilled the inclusion and exclusion criteria were treated as per protocol. Pre and post radiotherapy pain assessment was done for all the 22 metastatic sites. 7 vertebral metastases, 6 appendicular skeleton lesions, 9 non vertebral axial skeleton lesions were included. The most common primary disease was breast carcinoma closely followed by lung