ESTRO 2024 - Abstract Book

S1915

Clinical - Mixed sites, palliation

ESTRO 2024

carcinoma. 4 out of 7 vertebral metastases received 25Gy in 5 fractions.1 out of 16 patients had neurological symptom before radiotherapy in the form of reduced distal power and diminished sensation. Average pain score of 8 before treatment and immediate post treatment pain score being less than or equal to 4. Among the 20 patients, 7 patients completed their 6 month follow up; 9 patients completed their 3 month follow up pain assessment. 4 deaths reported within 3 months post treatment. Paired sample t-test was performed, comparing the pain scores before radiotherapy versus immediately after RT, at 3 months and at 6 months. There is a significant decrease in pain at all three time intervals with P score<0.05, 95% confidence interval. Any new neurological symptoms or worsening of pre-existing neuropathy noted. Incidence of skeletal events are also noted.

Conclusion:

By this study we propose that high dose palliation is an effective treatment option for patients with vertebral and spine metastases in a low resource setting using escalate dose fractionation regimen and provides considerable pain relief.

Keywords: pain relief, palliation, radiotherapy

References:

1.Timothy K Nguyen , Lee Chin , Arjun Sahgal , Roi Dagan , Wietse Eppinga , Matthias Guckenberger , Jin Ho Kim , Simon S Lo , Kristin J Redmond , Shankar Siva , Bradley J Stish , Rachel Chan, Liam Lawrence, Angus Lau, Chia-Lin Tseng. International Multi-institutional Patterns of Contouring Practice and Clinical Target Volume Recommendations for Stereotactic Body Radiation Therapy for Non-Spine Bone Metastases. Int J Radiat Oncol Biol Phys. 2022 Feb 1;112(2):351-360.

2.Tong D, Gillick L, Hendrickson FR. The palliation of symptomatic osseous metastases.Final results of the study by the Radiation Therapy Oncology Group. Cancer 1982 ; 50 : 893 – 9.

3. Arjun Sahgal , Joe H Chang , Lijun Ma , Lawrence B Marks , Michael T Milano , Paul Medin , Andrzej Niemierko , Scott G Soltys , Wolfgang A Tomé , C Shun Wong , Ellen Yorke , Jimm Grimm , Andrew Jackson. Spinal Cord Dose Tolerance to Stereotactic Body Radiation Therapy. Int J Radiat Oncol Biol Phys. 2021 May 1;110(1):124-136. doi:10.1016/j.ijrobp.2019.09.038. Epub 2019 Oct 10. 4.Ryu S, Deshmukh S, Timmerman RD, Movsas B, Gerszten P, Yin FF, Dicker A, Abraham CD, Zhong J, Shiao SL, Tuli R, Desai A, Mell LK, Iyengar P, Hitchcock YJ, Allen AM, Burton S, Brown D, Sharp HJ, Dunlap NE, Siddiqui MS, Chen TH, Pugh SL, Kachnic LA. Stereotactic Radiosurgery vs Conventional Radiotherapy for Localized Vertebral Metastases of the Spine: Phase 3 Results of NRG Oncology/RTOG 0631 Randomized Clinical Trial. JAMA Oncol. 2023 Jun 1;9(6):800 807. doi: 10.1001/jamaoncol.2023.0356. PMID: 37079324; PMCID: PMC10119775.

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