ESTRO 2024 - Abstract Book

S1977

Clinical - Mixed sites, palliation

ESTRO 2024

2612

Digital Poster

Assessing the efficacy of postoperative hypofractionated Radiation Therapy in Keloids

Jose Regis Neto, Og A Rodrigues

Oncovida, Radiation Therapy, Joao Pessoa, Brazil

Purpose/Objective:

Until nowadays, treatments for keloids remain challenging. Surgical excision followed by postoperative radiation therapy (RT) is considered by many specialists the treatment approach with the greatest success rate. The ideal RT dose and daily fractionation remains unclear, and many trials are demonstrating that hypofractionated schemes are safe and efficacious. In this trial, we conducted a retrospective analysis to evaluate the efficacy of hypofractionated RT for keloids in the most diverse topographies.

Material/Methods:

We accessed data from patients submitted to postoperative RT for keloids with a minimum follow up period of 12 months to estimate its efficacy and safety. All treatments analyzed were concluded before June of 2022.To be included in the analysis, patients must have strictly followed our institutional protocol in which it is mandatory to initiate the RT within 48h of the surgery,photographic and dimensions registries of the keloid before the surgical approach must be clearly specified in the medical records and all patients must have received the standard dose of 5 fractions of 400cGy using electrons beam technique. The keloid status after RT was assessed based on the clinical records of the last follow-up date, including clinical examination and/or photographic registry.

Results:

A total of 112 patients, mean age 35,6 years old, fulfilled all criteria and were included in the analyses.The most predominant topography of Keloids was in the abdominal wall(24%) followed by thoracic wall(19%) and breasts (19%). The mean size of the treated scars was 14,08 cm. In this study, the overall efficacy rate of postoperative RT for keloids was 78,5%, with a median follow-up of 32 months. Family history of keloids and previous unsuccessful RT to keloids were associated with greater risk of recurrence in multivariate analyses.

Conclusion:

Hypofractionated postoperative Radiation Therapy for keloids seems to be effective and safe to a great range of topographies. Nevertheless, family history and previous unsuccessful RT treatment may impact negatively in the clinical results.

Keywords: Keloids, Hypofractionation