ESTRO 2024 - Abstract Book

S2045

Clinical - Paediatric

ESTRO 2024

and long-term outcomes, 52 were alive and 47 were alive without disease at the last follow-up visit. There were 3.8% secondary tumours reported, with two meningiomas and one diffuse intrinsic pontine glioma. Respectively in the adult and paediatric cohorts, secondary cataract occurred in 4.3% and 22.0% of patients, 26.1% and 29.3% had persistent hearing disorders, 4.3% and 2.4% had pulmonary or cardiac late effect, 30.0 and 56.8% had pituitary gland hormonal deficiency; and 56.5% and 53.7% of the patients presented psycho-cognitive disorders.

Conclusion:

After helical tomotherapy craniospinal irradiation, there was no added acute nor late toxicity compared with 3DRT craniospinal irradiation, particularly no increase in second tumour rate, compared with literature 4,5,6 .

Keywords: CNS tumour, craniospinal irradiation, tomotherapy

References:

1. Mesbah L, Matute R, Usychkin S, et al: Helical tomotherapy in the treatment of pediatric malignancies: a preliminary report of feasibility and acute toxicity. Radiat Oncol 6:102, 2011

2. Seidel C, Heider S, Hau P, et al: Radiotherapy in Medulloblastoma—Evolution of Treatment, Current Concepts and Future Perspectives. Cancers 13:5945, 2021

3. Lopez Guerra JL, Marrone I, Jaen J, et al: Outcome and toxicity using helical tomotherapy for craniospinal irradiation in pediatric medulloblastoma. Clin Transl Oncol 16:96–101, 2014

4. Aldrich KD, Horne VE, Bielamowicz K, et al: Comparison of hypothyroidism, growth hormone deficiency, and adrenal insufficiency following proton and photon radiotherapy in children with medulloblastoma. J Neurooncol 155:93–100, 2021 5. Paulino AC, Ludmir EB, Grosshans DR, et al: Overall survival and secondary malignant neoplasms in children receiving passively scattered proton or photon craniospinal irradiation for medulloblastoma. Cancer 127:3865– 3871, 2021 6. Holmes JA, Chera BS, Brenner DJ, et al: Estimating the excess lifetime risk of radiation induced secondary malignancy (SMN) in pediatric patients treated with craniospinal irradiation (CSI): Conventional radiation therapy versus helical intensity modulated radiation therapy. Practical Radiation Oncology 7:35–41, 2017

1608

Proffered Paper

Pituitary dose predicts growth hormone deficiency in children: a multi-centre voxel-based analysis.

Angela Davey 1 , Lydia J Wilson 2 , Eliana Vasquez Osorio 1 , Andrew Green 1 , Kate Vaughan 1 , Peter E Clayton 3 , Lesley Albutt 1 , Marcel van Herk 1 , Martin G McCabe 1 , Thomas E Merchant 4 , Marianne C Aznar 1 1 The University of Manchester, Division of Cancer Sciences, Manchester, United Kingdom. 2 Thomas Jefferson University, Department of Radiation Oncology, Philadelphia, USA. 3 The University of Manchester, Division of