ESTRO 2024 - Abstract Book

S2049

Clinical - Paediatric

ESTRO 2024

Conclusion:

In two cohorts of children treated with brain radiotherapy for diverse diagnoses, we independently identified similar regions in the brain where higher dose was significantly associated with an increased risk of GHD. Both cohorts provide evidence that dose to the pituitary and surrounding areas should be reduced where possible, but further validation is required. Furthermore, hypothalamus and pituitary dose should be considered independently in outcome modelling as they may have unique dose-response relationships.

Keywords: dose response, late effects, radiotherapy

References:

1. Central Endocrine Complications Among Childhood Cancer Survivors Treated With Radiation Therapy: A PENTEC Comprehensive Review, Greg Wheeler at al., Int Jour Rad Bio Phys , https://doi.org/10.1016/j.ijrobp.2023.04.024.

2. Radiation dose to heart base linked with poorer survival in lung cancer patients, Alan McWilliam et al, Eur J Cancer , 2007. https://doi.org/10.1016/j.ejca.2017.07.053

3. Image-based data mining applies to data collected from children, Lydia J Wilson et al., Phys Med , 2022. https://doi.org/10.1016/j.ejmp.2022.05.003

4. OC-0776 Are MRI scans needed for precise image-based data mining in paediatric brain tumour cohorts, Abigail Bryce-Atkinson et al., Radiother Oncol , 2023. https://doi.org/10.1016/S0167-8140(23)08717-0

5. Voxel-based analysis: Roadmap for clinical translation, Alan McWilliam et al., Radiother Oncol , 2023. https://doi.org/10.1016/j.radonc.2023.109868

1719

Poster Discussion

Setup repeatability is similar for radiotherapy in DIBH and free-breathing in paediatric patients

Daniella Elisabet Østergaard 1 , Anni Young Lundgaard 2 , Hanne Krogh Rose 3 , Jolanta Hansen 3 , Lisa Lyngsie Hjalgrim 4 , Ivan Richter Vogelius 1,5 , Maja Vestmø Maraldo 1 1 University Hospital of Copenhagen, Section of Radiotherapy, Department of Oncology, Copenhagen, Denmark. 2 Odense University Hospital, Department of Oncology, Odense, Denmark. 3 Aarhus University Hospital, Section of Radiotherapy, Department of Oncology, Aarhus, Denmark. 4 University Hospital of Copenhagen, Department of Pediatric Haematology and Oncology, Copenhagen, Denmark. 5 Copenhagen University, Faculty of Health and Medical Sciences, Copenhagen, Denmark

Purpose/Objective:

Deep inspirational breath-hold (DIBH) is a standard motion management strategy for adults to spare normal tissue in mediastinum but is not used as a standard for children [1–4]. However, DIBH has been proven feasible