ESTRO 2024 - Abstract Book

S2055

Clinical - Paediatric

ESTRO 2024

1. Schoot RA, Hol MLF, Merks JHM, Suttie M, Slater O, van Lennep M, et al. Facial asymmetry in head and neck rhabdomyosarcoma survivors. Pediatr Blood Cancer. 2017 Oct;64(10).

2. Davey A, Pan S, Bryce-Atkinson A, Mandeville H, Janssens GO, Kelly SM, et al. The need for consensus on delineation and dose constraints of dentofacial structures in paediatric radiotherapy: Outcomes of a SIOP Europe survey. Clin Transl Radiat Oncol. 2023 Sep 24;43:100681.

3. CTCAE Files [Internet]. [cited 2023 Oct 24]. Available from: https://evs.nci.nih.gov/ftp1/CTCAE/About.html

2386

Digital Poster

Outcomes of Children Diagnosed with Unilateral Retinoblastoma: Retrospective Audit

Nehal Rishi Khanna 1,2 , Yogesh Rathod 1 , Jifmi Jose Manjali 1 , Mukta Ramadwar 3 , Poonam Panjwani 3 , Sajid Qureshi 4 , Badira Parambil 5 , Maya Prasad 5 , Girish Chinnaswamy 5 , Akshay Baheti 6 , Vasundhara Patil 6 , Kunal Gala 7 , Nandan Shetye 4 , Siddhartha Laskar 1 1 Tata Memorial Hospital, Radiation Oncology, Mumbai, India. 2 Homi Bhabha National University, HBNI, Mumbai, India. 3 Tata Memorial Hospital, Pathology, Mumbai, India. 4 Tata Memorial Hospital, Surgical Oncology, Mumbai, India. 5 Tata Memorial Hospital, Medical Oncology, Mumbai, India. 6 Tata Memorial Hospital, Radiology, Mumbai, India. 7 Tata Memorial Hospital, Interventional Radiology, Mumbai, India

Purpose/Objective:

To evaluate treatment outcomes of children diagnosed with unilateral retinoblastoma.

Material/Methods:

Retrospective study of children diagnosed with unilateral retinoblastoma registered at the Tata Memorial Hospital (TMH), Mumbai from January 2013 to December 2018 and completed the planned curative treatment protocol.

Results:

For the 98 cases that were analyzed, the median age of presentation was 24 months. The majority of patients had the intraocular disease (n=72), whereas orbital retinoblastoma was in 26 patients. At the time of presentation, on imaging extra scleral spread was observed in 16 patients whereas 18 patients had optic nerve involvement, 11 patients had both extra scleral invasion and optic nerve involvement. We used the International Classification of Retinoblastoma for grouping. Out of 98 patients, 71 patients were in Group E, 21 were in Group D and 4 were in Group B and 2 were in Group C. For Staging of Retinoblastoma, we used International Retinoblastoma Staging System (IRSS) in our study and 14 patients had Stage 0 disease, 52 patients had Stage I disease, 10 patients had Stage II, 21 patients had Stage III A and 1 patient had Stage III B disease. High-risk features on surgical specimen histopathology were optic nerve cut margin positive in 6 patients, optic nerve involvement in 21 patients, extra scleral spread in 3 patients, choroidal invasion in 38 and Iris involvement in 10 patients. Primary enucleation was offered in 52 patients whereas 26 patients underwent secondary enucleation. Systemic chemotherapy was received by the patient in the neoadjuvant setting in 17 patients as a form of chemo-reduction and 51 patients