ESTRO 2024 - Abstract Book

S2056

Clinical - Paediatric

ESTRO 2024

received systemic chemotherapy in the adjuvant setting. Intra-arterial chemotherapy was offered to 27 patients as a primary treatment or in conjugation with focal therapy (n=11). Definitive radiotherapy was offered to only 2 patients and 22 patients received adjuvant radiotherapy. At a median follow-up of 62 months, 2patients had local relapse, which was salvaged by focal therapy in one and enucleation in the other. Ten patients who had leptomeningeal relapse had died. The 5-year local control (LC) is 97.6%, event-free survival (EFS) is 88% and overall survival (OS) is 89.5%. Globe was salvaged in only 16 cases. On univariate analysis, we observed a significant association between overall survival and extraocular and intraocular disease (p-value 0.0), extra scleral spread (p-value 0.0), optic nerve involvement (imaging), and an optic nerve cut margin positive (p-value 0.045), ICRB Groups (p-value 0.0) and IRSS stage (p- value 0.024).

Conclusion:

Retinoblastoma is curable if detected early. Extra ocular disease and high risk features are associated with inferior outcomes and poor globe salvage rates.

Keywords: Retinoblastoma, outcomes, multidisciplinary

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Poster Discussion

HOPE to be PAST: Hair loss outcome prediction in paediatric patients after craniospinal irradiation

Camilla Satragno 1 , Irene Schiavetti 2 , Flavio Giannelli 3 , Salvina Barra 3 , Liliana Belgioia 2

1 University of Genoa, Department of Experimental Medicine (DIMES), Genoa, Italy. 2 University of Genoa, Departm. Department of Health Sciences (DISSAL)ent of Experimental Medicine (DIMES), Genoa, Italy. 3 San Martino Hospital, Radiation Oncology, Genoa, Italy

Purpose/Objective:

Permanent alopecia, after craniospinal irradiation (CSI) in childhood, remains a late effect with a negative impact on the patient's quality of life and on social life. The only definitive curative treatment is prevention.

Our study set out to design a two-stage research protocol to prevent this toxicity:

1. Say Goodbye to alopecia with PAST: The Pediatric Atlas - Based Scalp Segmentation Technique that may help to prevent hair loss in craniospinal irradiation.

2. HOPE: Hair Loss Outcome Prediction and Evaluation.

The first part of the study aimed to develop an atlas for automatic scalp segmentation in paediatric patients to increase the level of segmentation by reducing personal variability and saving time.

The second part aimed to identify the predictive variables for permanent alopecia and risk stratification using a multifactorial approach to prevent this permanent toxicity.