ESTRO 2024 - Abstract Book

S2091

Clinical - Sarcoma, skin cancer, melanoma

ESTRO 2024

1 Radiation Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy. 2 Department of Medical Physics, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy. 3 eDIMES Lab-Laboratory of Bioengineering, Department of Medical and Surgical Sciences - DIMEC, Alma Mater Studiorum University of Bologna, Bologna, Italy. 4 Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy. 5 Department of Medical and Surgical Sciences - DIMEC, University of Bologna, Bologna, Italy. 6 Oral and Maxillo-Facial Surgery Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy. 7 Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy. 8 Plastic Surgery Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy. 9 Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy

Purpose/Objective:

The aim of this study was to assess the feasibility of employing 3D printing technology to create patient-specific 3D printed boluses (3Db) for radiation therapy (RT) in the treatment of head and neck (H&N) skin tumors. Commercial boluses frequently encounter issues due to the irregular surface of patients' skin in H&N tumors, resulting in air gap effects and second skin sparing, which reduce both maximum and surface doses. Customizable 3Db, tailored to the intricacies of human anatomy in H&N skin tumors, were designed to mitigate these irregularities.

Material/Methods:

From patients treated at our institution for H&N cutaneous malignancies. These patients received RT with customized 3Db, either in the postoperative or radical setting. Our patient cohort included various histological types. The 3Db were created by first outlining them on a CT-simulation using our treatment planning system. Subsequently, they were fabricated using a CE-marked stereolithography 3D printer (Form 3B, Formlabs, Somerville, MA, USA) and a CE-marked photosensitive clear rigid resin (density: 1.15 g/cm3). Patients underwent CT simulation with the 3Db in place beneath the immobilization system mask, followed by RT planning. June 2021 to March 2023, we conducted a retrospective analysis of

Results:

A total of twenty patients with H&N skin tumors participated in the observational study (PORTO-1) and were treated with customized 3Db for RT, targeting areas such as the nose, cheek, periorbital region, or scalp (Table 1).