ESTRO 2024 - Abstract Book

S2094

Clinical - Sarcoma, skin cancer, melanoma

ESTRO 2024

Results:

Ten patients were included. Tumor was located in the limbs and in the trunk in respectively 8 and 2 patients. Mean age was 54.9 years (range: 19-69). Concurrent chemotherapy was performed in 2 patients. Mean GTV size was 793,70 cm3 (range: 59.8-3140). Mean PTV coverage by the 95% of the dose prescription was 98% (95-100) in both PTV1 and PTV2. Mean PTV1 and PTV2 Dmax were 61.6 Gy (range: 59-65) and 64 Gy (range:63-66), in both cases below the 107% threshold. Mean Bone Dmax was 57,6Gy (56.6-61.9 Gy). Dmax to the skin corridor exceeded 20 Gy in 2 patient (range 12.5-58.1). While the NVB was overlapping the PTV2 in 8 cases, Dmax was below 66 Gy. At the time of this report, no Grade ≥3 acute skin toxicity was observed. Among eight patients who underwent surgery at the time of the analysis, pCR and pNCR were obtained in two and 5 patients, respectively. No major wound complications were reported.

Conclusion:

Planning goals of the first 10 enrolled patients are achieved in most cases. Preliminary results show a benign safety profile and promising tumor response rate.

Keywords: Preoperative radiotherapy, soft tissue sarcoma

1439

Mini-Oral

Comparing toxicity in soft tissue sarcoma: preoperative radio-chemotherapy vs radiotherapy alone

Daniela Greto 1 , Mauro Loi 1 , Marco Banini 1 , Andrea Romei 1 , Ilaria Morelli 1 , Ilaria Bonaparte 1 , Domenico Andrea Campanacci 2 , Guido Scoccianti 2 , Giuliana Roselli 3 , Annarita Palomba 4 , Gabriele Simontacchi 1 , Carlotta Becherini 1 , Emanuela Olmetto 1 , Pietro Garlatti 1 , Icro Meattini 1 , Erika Scoccimarro 1 , Giulio Francolini 1 , Isacco Desideri 1 , Lorenzo Livi 1 1 Azienda Ospedaliero-Universitaria Careggi, Università di Firenze, Radiation Oncology, Florence, Italy. 2 Azienda Ospedaliero-Universitaria Careggi, Università di Firenze, Orthopedic Oncology and Reconstructive Surgery, Florence, Italy. 3 Azienda Ospedaliero-Universitaria Careggi, Università di Firenze, Radiology, Florence, Italy. 4 Azienda Ospedaliero-Universitaria Careggi, Università di Firenze, Histopathology and Molecular Diagnostic Unit, Florence, Italy

Purpose/Objective:

Preoperative radiotherapy is a mainstay of soft tissue sarcoma (STS) management, despite higher risk of wound dehiscence as compared to postoperative radiotherapy (up to 25% in landmark trials). Addition of preoperative concurrent chemotherapy has been proposed to increase tumor response before surgery, although caution has been raised due to possible increase in toxicity, surgical complications and treatment interruptions. A matched