ESTRO 2024 - Abstract Book

S2095

Clinical - Sarcoma, skin cancer, melanoma

ESTRO 2024

cohort analysis was performed in STS patients to analyze differences in terms of toxicity, complications and margin status between patients treated with concurrent radio-chemotherapy (RTCT) and radiotherapy (RT) alone.

Material/Methods:

Patients were treated from January 2010 to October 2022. For each patient in the RT group a patient in the RTCT group matching for age, tumor size and location was selected. Radiotherapy was delivered to a dose of 50 Gy in 25 fractions. Chemotherapy consisted of 3 cycles of Epirubicin-Ifosfamide every 21 days. Clinical and treatment related data were collected. Acute skin toxicity incidence graded according to the CTCAE v 5.1, wound complication rate and RT interruption were compared between the two groups using the Chi-square test.

Results:

Eighty-four patients were included (42 RT, 42 RTCT). Median age was 55 years (range 19-83). Use of RTCT was correlated with FNCLCC grade 3 disease at diagnosis (p<0.001). All patients completed the preoperative treatment schedule and underwent wide excision: R0 resection was obtained in 90% of cases (n=77). Grade 2 and 3 acute skin toxicity was recorded in respectively 18 (21%) and 5 (6%) patients. Wound dehiscence occurred in 13 patients (15%). Treatment interruption occurred in 32 patients, for a median of 3 days (range 1-18). No statistically significant differences were found between RT and RTCT in terms of wound dehiscence (14% vs 15%, NS), Grade ≥2 toxicity (22% vs 33%, NS) and RT interruption (14% vs 18%, NS). No correlation between treatment arm and R0 resection rate was found (93% vs 87%, NS)

Conclusion:

Preoperative RTCT association in STS patients eligible for surgery was not correlated with increased acute toxicity, wound dehiscence and RT interruption. Due to low incidence of marginal resections, larger cohorts are needed to assess the benefit of combined treatment in increasing R0 resection rate

Keywords: Soft tissue sarcoma, toxicity, preoperative RT-CT

1509

Mini-Oral

Conventional vs hypofractionated pre-op RT in localised STS – clinical significance of tumour necrosis

Hanis Hanafi 1 , Carolyn Freeman 1 , James Tsui 1 , Paul Ramia 1 , Robert Turcotte 2 , Ahmed Aoude 2 , Anthony Bozzo 2 , Fabio Cury 1 1 McGill University Health Centre, Radiation Oncology, Montreal, Canada. 2 McGill University Health Centre, Orthopaedic Surgery, Montreal, Canada