ESTRO 2024 - Abstract Book

S2117

Clinical - Sarcoma, skin cancer, melanoma

ESTRO 2024

Conclusion:

Sarcoma treatment patterns in Germany match the German S3 and NCCN guideline recommendations. The use of RT is not beneficial in terms for survival and non-progression for UICC stage I STS. For UICC stage II STS, adjuvant RT might be benefical in terms of OS compared to neoadjuvant RT. Tumor localization, histological grade, T-, N- and M stage, treatment strategies and resection-status were found to be prognostic factors in terms of survival.

Keywords: Sarcoma, Treatment patterns, cancer registry

2425

Digital Poster

Clinical pathological characteristics, pattern of care and survival of non-metastatic Angiosarcoma.

Mauro Loi, Daniela Greto, Emanuela Olmetto, Pietro Garlatti, Erika Scoccimarro, Icro Meattini, Luca Visani, Viola Salvestrini, Anna Peruzzi, Pierluigi Bonomo, Ilaria Morelli, Ilaria Bonaparte, Lucia Angelini, Marco Banini, Andrea Romei, Lorenzo Livi

Radiation Oncology, Azienda Ospedaliero Universitaria Careggi, Florence, Italy

Purpose/Objective:

Angiosarcoma (AS) is a rare soft tissue sarcoma subtype that may arise de novo or in previously irradiated patients. Due to its scarce incidence, prognostic factors and optimal pattern of care are ill-defined. The aim of this study is to investigate the clinicopathological features, treatment modalities and outcome of AS.

Material/Methods:

Clinical and treatment-related data from consecutive non-metastatic patients treated at our Institution from June 2006 to December 2020 were retrospectively reviewed. Local control (LC), Distant Metastasis-Free Survival (DMFS), Overall Survival (OS) were calculated using the Kaplan ‐ Meier method and compared with log ‐ rank test.

Results:

Twenty-two patients were included in the analysis. Median age was 60 (17-86) years. In 15 patients, AS arose in a previously irradiated field following adjuvant radiotherapy of prior breast adenocarcinoma. No information on pre existing edema were available. All patients underwent surgery consisting of wide excision and mastectomy in 6 and 16 cases respectively.Grade 3 FNCLCC disease was identified in 7 patients. Postoperative radiotherapy and chemotherapy were required in respectively 5 (median dose 60 Gy, range 25-66 Gy) and 3 patients. At the time of our analysis after a median follow-up of 36 months disease recurrence occurred as local, distant, and concurrent distant and local failure in 3, 6 and 6 patients. Three-years LC, DMFS and OS rate were 59%, 51% and 76%