ESTRO 2024 - Abstract Book

S2118

Clinical - Sarcoma, skin cancer, melanoma

ESTRO 2024

respectively. At statistical analysis, only deep-seated tumors were correlated with impaired DMFS (29 months vs NR, p=0.0043) and OS (29 months vs NR, p=0.001), while no correlation was found between outcome and previous irradiation.

Conclusion:

AS is characterized by poor outcomes, and may require treatment intensification with more extended surgery due to prior management and possible prognostic role of deep-seated tumor.

Keywords: Angiosarcoma; survival; treatment

2793

Mini-Oral

Clinical and toxicity outcomes with preoperative radiation therapy in a large cohort of STS patients

Mauro Loi 1 , Daniela Greto 1 , Marco Banini 1 , Marianna Valzano 1 , Andrea Romei 1 , Ilaria Morelli 1 , Ilaria Bonaparte 1 , Gabriele Simontacchi 1 , Carlotta Becherini 1 , Erika Scoccimarro 1 , Giulio Francolini 1 , Viola Salvestrini 1 , Pierluigi Bonomo 1 , Anna Peruzzi 1 , Stefania Pallotta 2 , Giuliana Roselli 3 , Domenico Campanacci 4 , Scoccianti Guido 4 , Palomba Annarita 5 , Monica Mangoni 1 , Icro Meattini 1 , Lorenzo Livi 1 1 Azienda Ospedaliero Universitaria Careggi, Università di Firenze, Radiation Oncology, Firenze, Italy. 2 Azienda Ospedaliero Universitaria Careggi, Università di Firenze, Medical Physics, Firenze, Italy. 3 Azienda Ospedaliero Universitaria Careggi, Università di Firenze, Radiology, Firenze, Italy. 4 Azienda Ospedaliero Universitaria Careggi, Università di Firenze, Oncologic Orthopedic Surgery, Firenze, Italy. 5 Careggi University Hospital, Histopathology and Molecular Diagnostic Unit, Firenze, Italy

Purpose/Objective:

Primary therapy for Soft Tissue Sarcoma (STS) mostly consists of a combination of surgery and radiation therapy (RT). Preoperative RT has the advantage of requiring lower dose delivering and of giving the possibility of tumor downstaging, particularly in association with chemotherapy (CT) and modern radiation techniques. The present study aimed to evaluate efficacy and toxicity outcomes study and prognostic-related features in STS patients treated with preoperative RT and surgery.

Material/Methods:

Clinical and treatment related data were collected from consecutive STS patients treated at our Institution with preoperative RT followed by surgery from 1991 to 2023. Only patients for whom follow-up data was available, were included. Overall survival (OS), Distant-metastasis free survival (DMFS), Local control (LC) data were collected and