ESTRO 2024 - Abstract Book

S2121

Clinical - Sarcoma, skin cancer, melanoma

ESTRO 2024

Two schemes were used depending on the surface affected. In patients with involvement of more than 50% of the limb circumference, which was in 50% of the patients, we used the schedule by 4 Gy per fraction, in total 6 fractions, total dose 24 Gy (1 day a week).

Another group with less than 50% circumference affected, we used 2 Gy per fraction in 15 fractions, total dose 30 Gy (5 days a week).

Applied technique was VMAT with 6x energy for all patients.

Immobilization system used - vacuum mattress

Results:

5 years follow up with mediana of 2,5 years. Complete response was archived in 97%, In 2% of patients -stabilization of the cutaneous lesions and in 1% observed progression.

Stabilization or progression was associated with deep skin invasion and ulcers.

Toxicity reported in 20% of patients acute dermal toxicity G1 and in 80%-G2. No G3 was observed.

Late toxicity-fibrosis was reported in 30% of patients.

Conclusion:

Kaposi sarcoma is highly radiosensitive disease and in most cases a complete response was achieved. There was no difference between the two regimens regarding complete response, nor regarding acute or late toxicity.

In cases of very large surface areas, the use of fractionation once a week is recommended in terms to prevent development of edema during of treatment.

Keywords: Caposi sarcoma, VMAT

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Azienda Ospedaliero Universitaria Careggi, Università di Firenze, Radiation Oncology, Firenze, Italy