ESTRO 2024 - Abstract Book

S2163

Clinical - Upper GI

ESTRO 2024

Definitive-dose RT/CRT after ESD for esophageal cancer with high-risk lymph node metastases can achieve favorable PFS and OS. Notably, no lymph node metastasis was observed in the areas irradiated with >= 50 Gy; however, definitive-dose RT/CRT could not prevent the esophagus recurrence and distant organ metastasis. Over 50% of the patients suffered grade 3 or more severe late toxicities, with cardiotoxicity being particularly prevalent, subsequent to definitive-dose RT/CRT involving irradiation from two opposing fields. Age emerged as a distinct prognostic factor for both PFS and OS in adjuvant definitive RT/CRT after ESD.

Keywords: minimally invasive treatment

References:

1 K. Minashi et al. Gastroenterol 2019, 157(2): 382-390.

2 K. Nihei et al. Gastroenterol 2023, 164(2): 296-299.

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Digital Poster

Treatment outcomes of definitive radiotherapy for synchronous cancers of the pharynx and esophagus

Yuki Wada, Satoshi Kumagai, Tetsugaku Shinozaki, Toshiki Murata, Daichi Sugawara, Noriko Takagi, Naoko Mori

Akita University Graduate School of Medicine, Radiology, Akita, Japan

Purpose/Objective:

Although pharyngeal and esophageal cancers sometimes occur synchronously, there is no established treatment strategy for synchronous double cancers. Definitive chemoradiotherapy (CRT)/radiotherapy (RT) is a curative treatment that can preserve organs in both the pharynx and esophagus; however, the safety of simultaneously irradiating the pharynx and esophagus, in which the irradiation field is larger than that of irradiation to each side individually, has not been established. The aim of this retrospective analysis of patients who underwent definitive CRT/RT for synchronous pharyngeal and esophageal cancers is to reveal adverse events and completion rates. In addition, prognosis after CRT/RT was investigated; however, the analysis was limited due to the heterogeneity of sublocations and stages of the diseases.

Material/Methods:

Between 2002 and 2022, 30 patients underwent CRT/RT simultaneously for pharyngeal and esophageal cancers. Of these, 9 patients were excluded from the present study for the following reasons: did not undergo definitive-intent radiotherapy such as adjuvant radiotherapy after surgery, 1 patient with head and neck cancer had a malignant lymphoma, and 1 with esophageal cancer underwent salvage irradiation for recurrence after surgery. In total, 21 patients (20 males and 1 female; median age 70 years; range 47 – 85 years) were included in the present study.