ESTRO 2024 - Abstract Book

S2191

Clinical - Upper GI

ESTRO 2024

Keywords: lymphopenia, esophageal cancer, proton RT

References:

1. Dai, D. et al. Severe Radiation-Induced Lymphopenia Affects the Outcomes of Esophageal Cancer: A Comprehensive Systematic Review and Meta-Analysis. Cancers vol. 14 Preprint at https://doi.org/10.3390/cancers14123024 (2022).

2. Xu, C. et al. The impact of the effective dose to immune cells on lymphopenia and survival of esophageal cancer after chemoradiotherapy. Radiotherapy and Oncology 146, (2020).

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Influence of nutritional status on survival in esophageal cancer patients undergoing RT and surgery

Ilaria Morelli 1 , Mauro Loi 1 , Pierluigi Bonomo 1 , Carlotta Becherini 1 , Daniela Greto 1 , Emanuela Olmetto 1 , Pietro Garlatti 1 , Icro Meattini 1 , Gabriele Simontacchi 1 , Erika Scoccimarro 1 , Luca Visani 1 , Monica Mangoni 1 , Vanessa Di Cataldo 1 , Viola Salvestrini 1 , Marianna Valzano 1 , Silvia Calusi 2 , Antonella Compagnucci 2 , Lorenzo Livi 1 1 Azienda Ospedaliero-Universitaria Careggi, Università di Firenze, Radiation Oncology, Florence, Italy. 2 Azienda Ospedaliero-Universitaria Careggi, Università di Firenze, Medical Physics Unit, Florence, Italy

Purpose/Objective:

Nutritional status might impair survival outcomes in EC patients. Aim of this retrospective analysis was to evaluate the impact of nutritional assessment in EC patients undergoing preoperative RT and subsequent surgery.

Material/Methods:

We retrospectively collected data of locally advanced (LA) EC patients treated with pre-operative RT with or without platinum-based chemotherapy (CT) and subsequent esophagectomy between November 2004 and April 2023. Clinical and treatment related data were collected. Acute and late toxicities were assessed. Descriptive, univariate (UVA) and multivariate (MVA) survival analysis was performed to identify correlation between enteral nutrition and survival outcomes.

Results:

54 patients (AC:n=25; SC:n=29) were included. Median age was 61 (42-82); ECOG-PS 0 in 41 patients. Jejunostomy feeding tube (JFT) was performed in 24 patients. Dysphagia was reported in 42 cases (7 cases of complete anorexia). Baseline weight loss (≥ 10% in 11 cases) was reported in 37. Median basal BMI was 21.8 kg/mq (13.6 -28.2). Clinical nodal involvement was present in 21 cases. Patients received a CROSS schedule, Cisplatin-5Fluorouracil or exclusive