ESTRO 2024 - Abstract Book

S2192

Clinical - Upper GI

ESTRO 2024

RT in 45, 7 and 2 cases, respectively. All patients underwent planned surgery. Acute toxicity consisted mainly of grade (G) ≤2 esophagitis (n=20) or pneumonitis (n=2). Two patients developed tracheobronchial fistula after surgery, 1 stenosis and 1 experienced gastric stump necrosis. In those treated with concurrent CT, G3-4 hematologic toxicity occurred in 12 cases. After a median follow-up of 41 (2-192) months, 3-year overall survival (OS), local recurrence (LRFS) and distant metastases (DMFS) free survival was 60%, 88% and 46% (fig. 1A, B, C). ECOG PS0 only (p=0.0095) was correlated with OS at UVA. At UVA, fistula only (p=0.0065) was related to LRFS. Concerning DMFS, pCR (p=0.045) and yN0 (p=0.0078) showed a significant correlation at UVA, although only yN0 proved significant at MVA (p=0.013) (fig. 1D, E, F). Dysphagia, weight loss and the use of JFT did not affect survival outcomes neither at UVA nor at MVA analysis. Chi square test showed significant correlation between JFT insertion and dysphagia (p<0.0012) and between JFT and weight loss >5% (p=0.0001).

Conclusion:

Our analysis did not show differences in survival outcomes according to nutritional status; this could be attributed to early insertion of JFT in patients with higher baseline weight loss and dysphagia.

Keywords: esophageal cancer, nutrional status, survival

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Secondary analysis of a multicenter observational study in pancreatic cancer.

Alessandra Arcelli 1 , Giuseppe Tarantino 2 , Francesco Cellini 3,4 , Milly Buwenge 5 , Gabriella Macchia 6 , Federica Bertini 7 , Alessandra Guido 1 , Francesco Deodato 3,6 , Savino Cilla 8 , Valerio Scotti 9 , Maria Elena Rosetto 10 , Igor Djan 11 , Salvatore Parisi 12 , Gian Carlo Mattiucci 3,13 , Michele Fiore 14 , Pierluigi Bonomo 15 , Liliana Belgioia 16 , Rita Marina Niespolo 17 , Pietro