ESTRO 2024 - Abstract Book

S2212

Clinical - Upper GI

ESTRO 2024

Figure 1: Scatter plot depicting 3-year local control rates after SBRT and HCV prevalence in 21 studies. Two studies did not report 3-year outcomes and are excluded from this figure. Circle diameters are proportional to sample size, and the solid line depicts the results of weighted least-squares linear regression.

Figure 2: Kaplan Meier curves depicting pooled local control outcomes for patients from studies with high (>2/3) and low (<1/3) prevalence of HCV infection.

Conclusion:

SBRT yields high rates of local disease control for HCC. Particularly high rates of local control have been observed in patients with a history of HCV infection. As this association has not been seen for other forms of liver-directed therapy, SBRT may be a preferred treatment approach for HCC caused by HCV. 4 Additional studies to understand the mechanisms behind our findings are warranted.