ESTRO 2024 - Abstract Book

S2335

Clinical - Urology

ESTRO 2024

In this work, we have demonstrated that GAN self-learning synthetic-CT generated from anatomy of day CBCT performs better than Ethos based synthetic-CT when it comes to full-scale dose calculation in the scope of adaptive treatment. Both relative dose difference and global gamma pass rates showed better results for the self-learning GAN solution of sCT_Thera than the current synthetic solution of Ethos system.

Keywords: Adaptive, synthetic-CT from CBCT, Dose calculation

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prognostic significance of lymphocyte ratio in patients under trimodality therapy for bladder cancer

Yu-Chen Chang 1 , Din-Li Tsan 1 , Wing-Keen Yap 1 , Kan-Hsing Fan 2 , Eric Yi-Liang Shen 1,3 , Yao-Yu Wu 1,4

1 Linkou Chang Gung Memorial Hospital, Department of Radiation Oncology and Proton Therapy Center, Taoyuan City, Taiwan. 2 New Taipei Municipal Tucheng Hospital, Department of Radiation Oncology, New Taipe City, Taiwan. 3 Imperial College London, Department of Metabolism, Digestion, and Reproduction, Faculty of Medicine, London, United Kingdom. 4 Chang Gung Memorial Hospital, Keelung, Department of Radiation Oncology, Keelung, Taiwan

Purpose/Objective:

The neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR) are commonly used as indicators of inflammation in various clinical scenarios. This study aimed to evaluate their prognostic value in relation to clinical outcomes in patients undergoing trimodality therapy (TMT) for muscle invasive bladder cancer (MIBC).

Material/Methods:

This was a retrospective analysis of prospectively collected data. We determined pretreatment lymphocyte ratios in 102 patients with MIBC who received TMT and assessed their associations with 2-year locoregional control (LRC), progression-free survival (PFS), distant metastasis-free survival (DMFS), and overall survival (OS) rates. The optimal cut-off points for lymphocyte ratios were determined through receiver operating characteristic curve analysis, utilizing the Youden’s index.

Results:

Patients with low NLR and high LMR consistently had more favorable outcomes across all four endpoints in univariate analysis. Although no association was observed with LRC or PFS, low PLR values were correlated with higher DMFS and OS rates. Notably, among high-risk patients with low LMR, radiation dose boosting after transurethral resection of bladder tumor (TURBT) was associated with more favorable LRC and PFS rates, although no significant improvement in OS and DMFS was observed.