ESTRO 2024 - Abstract Book

S2400

Clinical - Urology

ESTRO 2024

toxicity rate in patients undergoing ADT remain less clear. This finding, although consistent with some previous reports, warrants further investigation

Keywords: prostate,toxicity,salvage

1146

Digital Poster

Treatment factors and late toxicity in prostate cancer salvage radiotherapy: 454 patients’ results.

Letizia Cavallini 1,2 , Elena Natoli 1,2 , Maria Ntreta 2 , Filippo Mammini 1,2 , Silvia Paolinelli 1,2 , Erika Galietta 1,2 , Viola Laghi 1,2 , Milly Buwenge 1 , Giorgio Coco 1,2 , Alessandra D'Alterio 1,2 , Pietro Del Pia 1 , A. F. M. Kamal Uddin 3 , Mostafa A. Sumon 3 , Gabriella Macchia 4 , Francesco Deodato 4,5 , Selena Ciabatti 6 , Annalisa Cortesi 7 , Michele Benedetti 8 , Antonio Malorgio 9 , Ilaria Moschini 10 , Francesca Maurizi 11 , Savino Cilla 12 , Silvia Cammelli 1,2 , Alessio Giuseppe Morganti 1,2 , Alessandra Arcelli 2 1 Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna, Bologna, Italy. 2 Radiation Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy. 3 Department of Radiation Oncology, United Hospital Limited, Dhaka, Bangladesh, Dhaka, Bangladesh. 4 Radiation Oncology Unit, Gemelli Molise Hospital-Università Cattolica del Sacro Cuore, Campobasso, Italy. 5 Istituto di Radiologia, Università Cattolica del Sacro Cuore, Roma, Italy. 6 Radiotherapy Department, Ospedale Bellaria, Bologna, Italy. 7 Radiotherapy Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy. 8 Radiotherapy Department, Ospedale Infermi, Rimini, Italy. 9 Deparment of Radiotherapy, Azienda Ospedaliero-Universitaria di Ferrara, Ferrara, Italy. 10 Radiotherapy Department, Azienda Ospedaliero-Universitaria di Piacenza, Piacenza, Italy. 11 Radiation Oncology, A.O. Ospedali Riuniti Marche Nord, Pesaro, Italy. 12 Medical Physics Unit, Gemelli Molise Hospital Università Cattolica del Sacro Cuore, Campobasso, Italy

Purpose/Objective:

This study aimed to analyze the impact on late toxicity, in prostate cancer (PCa) patients treated with salvage radiotherapy (SRT) of several treatment-related parameters.

Material/Methods:

For this analysis, data from PCa patients undergoing SRT were extracted from the database of a multicenter observational study. Endpoints of the analysis were 5- year grade ≥ 2 and ≥ 3 gastrointestinal (GI) and genitourinary (GU) late toxicity-free survival. The following parameters were correlated with adverse events: prophylactic nodal irradiation (PNI; yes vs not), hypofractionation (yes vs not), lymphadenectomy (no vs < 15 nodes vs ≥ 15 nodes), EQD2α/β3 to the prostate bed (< vs ≥ median value), EQD2α/β3 to the pelvic nodes (< vs ≥ median value), radiotherapy technique (3D-conformal RT vs IMRT/VMAT), image guidance (EPID vs cone-beam/CT), previous abdominal-pelvic surgery (yes vs not), adjuvant androgen deprivation therapy (ADT; yes vs not), and type of ADT (LH-RH agonists vs high dose bicalutamide). Late toxicity was scored using the RTOG/EORTC scale.