ESTRO 2024 - Abstract Book

S2401

Clinical - Urology

ESTRO 2024

Results:

Four hundred fifty-four PCa patients were enrolled in this analysis. Overall, 5- year grade ≥ 2 and ≥ 3 late GI toxicity free survival was 91.5% and 97.7%, respectively. In addition, 5- year grade ≥ 2 and ≥ 3 late GU late toxicity -free survival was 81.6% and 95.8%, respectively. No grade 4-5 toxicities were recorded. Table 1 shows the results of the analysis. At univariate analysis, patients treated with hypofractionation (vs conventional fractionation) and those irradiated with modulated techniques (IMRT/VMAT vs 3D-CRT) showed a significant reduction in late GI toxicity grade ≥ 2 and grade ≥ 3. However, the multivariate analysis did not confirm these correlations. Furthermore, no parameter significantly predicted any grade's GU toxicity in univariate and multivariate analysis.

Table 1: Five- year late gastrointestinal and genitourinary toxicity Grade ≥ 2 and Grade ≥ 3.

Conclusion:

SRT of PCa was well tolerated regardless of treatment techniques. Considering the growing body of evidence on the efficacy of higher-than-standard (66-70 Gy) doses and PNI, at least in some patient subgroups, it is interesting to note that both parameters were not correlated to worse late toxicity.