ESTRO 2024 - Abstract Book

S2428

Clinical - Urology

ESTRO 2024

1 Aarhus University Hospital, Danish Centre for Particle Therapy, Aarhus, Denmark. 2 Fondazione IRCCS Istituto Nazionale dei Tumori, Data Science, Milan, Italy. 3 Azienda Sanitaria dell’Alto Adige, Department of Radiotherapy, Bolzano, Italy. 4 Fondazione IRCCS Istituto Nazionale dei Tumori, Department of Radiation Oncology, Milan, Italy. 5 Ospedale Regionale Parini- AUSL Valle d’Aosta, Department of Radiotherapy, Aosta, Italy. 6 IRCCS Istituto Tumori ‘Regina Elena’, Department of Radiotherapy, Rome, Italy. 7 Humanitas Gavazzeni, Department of Radiotherapy, Bergamo, Italy. 8 Azienda Ospedaliero Universitaria S. Maria della Misericordia, Department of Radiotherapy, Udine, Italy. 9 ASL TO4 Ospedale di Ivrea, Department of Radiotherapy, Ivrea, Italy. 10 Ospedale degli Infermi, Department of Radiotherapy, Biella, Italy. 11 Istituto di Candiolo – Fondazione del Piemonte per l‘Oncologia IRCCS, Department of Radiotherapy, Candiolo, Italy. 12 IRCCS CROB, Department of Radiotherapy, Rionero in Vulture, Italy. 13 Provincial Hospital of Bolzano (SABES-ASDAA), Department of Health Physics, Bolzano, Italy. 14 IRCCS San Raffaele Scientific Institute, Department of Medical Physics, Milan, Italy. 15 IRCCS San Raffaele Scientific Institute and Universitá Vita Salute San Raffaele, Department of Radiotherapy, Milan, Italy. 16 Medical University of Vienna, Department of Radiation Oncology, Comprehensive Cancer Center, Vienna, Austria. 17 IRCCS San Raffaele Scientific Institute, Department of Radiotherapy, Milan, Italy

Purpose/Objective:

To evaluate time patterns of erectile function and other sexual health domains after radical radiotherapy for localized prostate cancer (PCa) patients.

Material/Methods:

The analysis included outcome data from a multi-institutional prospective study on PCa treated with radiotherapy (2010-2014). Information on sexual health was recorded with the International Index of Erectile Function (IIEF) questionnaire (1) at baseline, at the end of treatment, at three months after the end of treatment, at six months, and thereafter every six months. IIEF includes domains for:

1. erectile function (EF); 2. orgasmic function (OF); 3. sexual desire (SD); 4. intercourse satisfaction (IS); 5. overall satisfaction (OS).

The current analysis refers to assessments from baseline up to 24 months for patients not receiving androgen deprivation therapy (ADT). Patients never reporting sexual activity/intercourse were excluded. To explore the temporal evolution of IIEF domains, dynamic time warping (2) was used to calculate distances between patients’ trajectories and hierarchical clustering (3) was applied to find clusters of patients with similar scoring patterns over time. The number of clusters was determined with the elbow method (4). This methodology was applied to group patients based on the evolution of scores over time for each IIEF domain. Statistically significant differences (p≤0.05) in clinical factors (age, smoking status, diabetes, hypertension, body mass index, Gleason score) between EF clusters were tested with Kruskal-Wallis or chi-square for continuous or binary variables, respectively.

Associations between EF clusters and other IEEF domains were also investigated.