ESTRO 2024 - Abstract Book

S2429

Clinical - Urology

ESTRO 2024

Results:

The analysis included 185 hormone-naïve patients with median age equal to 72 years (interquartile range:69-75). As shown in Figure1, 6 clusters for scoring patterns over time were found for patients in all IIEF domains, except OF where 4 clusters were identified. Higher scores correspond to higher functioning, desire or satisfaction. Considering EF, 30% of patients had a stable-low score (A+B), while 38% were high functional at baseline and stable with only slight worsening (~5-points) during follow-up (D+F). A considerable worsening compared to high function before treatment was experienced by 24% of patients (E). Two clusters (D+B) showed decline in OF, but from different baseline levels. The largest group (38%) had stable-low OF (A), while another group improved over time (C). Most clusters for SD were stable, but from different baseline levels, and only 15% of patients worsened more consistently (D). Comparable clusters were found for IS and OS: two groups of patients had consistently low (A) and high (F) scores, while other two groups worsened of ≥3 points compared to baseline. Other groups of comparable size had stable score from different baseline levels. To evaluate the association with other IIEF domains, EF clusters were grouped according to stable-low (A+B), stable high (D+F) and worsening (C+E) scores over time. The other IIEF domains clusters were grouped for stable-low, stable-medium, stable-high and worsening scores. Figure2 shows the overlap between EF and other domains according to this grouping. As patterns were redundant with IS, results are only shown for OS. Most patients with worsening EF had stable-low/worsening OF and SD. However, a comparable proportion of patients with stable-high EF score also reported stable-low/worsening SD (~60%). Despite stable-low EF scores, 40% of patients in this group were rather satisfied with their sexual life. On the other hand, half of the patients with stable-high EF had worsening OS scores. Patients with worsening EF also reported a decline in OS (~40%). However, >40% of patients in this group had stable-medium or high OS score. Statistically significant differences in clinical factors between EF clusters were found only for age (p<0.01).