ESTRO 2024 - Abstract Book

S2431

Clinical - Urology

ESTRO 2024

3. Kaufman L & Rousseeuw PJ (1990). Finding Groups in Data: An Introduction to Cluster Analysis (1 ed.). New York: John Wiley.

4. Ciaramella A, Nardone D & Staiano A. Data integration by fuzzy similarity-based hierarchical clustering. BMC Bioinformatics 21 (Suppl 10), 350 (2020).

The study was supported by an AIRC grant (IG14603) and JTC ERA PerMed 2020, PerPlanRT Project - Italian Ministry of Health ERP-2020-23671125.

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Digital Poster

First CR after radical prostatectomy: choline/PSMA-PET or mpMRI guided-SBRT on prostate bed relapse

Riccardo Santamaria 1,2 , Lorenzo Colombi 1,2 , Giulia Corrao 1 , Mattia Zaffaroni 1 , Maria Giulia Vincini 1 , Dario Zerini 1 , Lorenzo Muraglia 3 , Sarah Alessi 4 , Giulia Marvaso 1 , Francesco Ceci 2,3 , Giuseppe Petralia 2,4 , Gennaro Musi 5 , Barbara Alicja Jereczek-Fossa 1,2 1 European Institute on Oncology, Division of Radiation Oncology, Milan, Italy. 2 University of Milan, Department of Oncology and Hemato-Oncology, Milan, Italy. 3 European Institute on Oncology, Division of Nuclear Medicine, Milan, Italy. 4 European Institute on Oncology, Division of Radiology, Milan, Italy. 5 European Institute on Oncology, Division of Urology, Milan, Italy

Purpose/Objective:

Local recurrence on prostate bed occurred in about 30% of PCa patients (pts) after surgery. Diagnostic imaging has made significant advances in recent years, expanding and refining the diagnostic potential and enabling precise detection of disease recurrence. However, the most appropriate diagnostic approach and salvage RT for this clinical setting remains a matter of debate. SBRT treatments made it possible to target only the tissue affected by the recurrence, achieving excellent local control with an optimal safety profile. The aim of the present study is to evaluate the efficacy and safety of SBRT on the detectable prostate bed recurrence on our cohort.

Material/Methods:

RT-naïve men who underwent SBRT to macroscopic bed recurrence after RP were retrospectively considered. All patients were treated based on multiparametric (mp) MRI or choline/PSMA PET. Continuous variables were summarized as mean/median and interquartile range/range, while categorical variables were presented with absolute and relative frequencies. Toxicities were collected according to the RTOG scale. Kaplan – Meyer analysis and Cox regression were performed to explore the association between prognostic factors and biochemical recurrence (BCR) and clinical recurrence (CR).

Results: