ESTRO 2024 - Abstract Book

S2517

Clinical - Urology

ESTRO 2024

Conclusion:

Still too little is known about the significance and the duration over time of hematological toxicity in men receiving WPRT for the treatment of PCa. Although undoubtedly advisable in patients with high-risk PCA due to its potential role in the early eradication of occult lymph nodal metastases, WPRT is not frequently delivered, mainly owing to the fear of intestinal toxicities. With the present work we aimed at shining a light on how hematological toxicity, and lymphopenia in particular, may be non-negligible for a not inconsiderable fraction of PCa patients receiving WPRT ([1], [2]). Five years after RT end, WBC, ALC, ANC and RBC were still significantly different from their baseline levels.

Keywords: Hematological toxicity, Lymphopenia, PCa

References:

Current study was supported by a grant from AIRC (Associazione Italiana Ricerca Cancro) – Investigational Grant #14603.

[1] C. Cozzarini et al., Hematologic Toxicity in Patients Treated With Postprostatectomy Whole-Pelvis Irradiation With Different Intensity Modulated Radiation Therapy Techniques Is Not Negligible and Is Prolonged: Preliminary Results of a Longitudinal, Observational Study, International Journal of Radiation Oncology Biology Physics, Volume 95, Issue 2, 2016, Pages 690-695, ISSN 0360-3016, https://doi.org/10.1016/j.ijrobp.2016.01.022. [2] C. Sini, Dose – volume effects for pelvic bone marrow in predicting hematological toxicity in prostate cancer radiotherapy with pelvic node irradiation, Radiotherapy and Oncology, Volume 118, Issue 1, 2016, Pages 79-84, ISSN 0167-8140, https://doi.org/10.1016/j.radonc.2015.11.020.