ESTRO 2024 - Abstract Book

S2523

Clinical - Urology

ESTRO 2024

Keywords: Adaptive, Seminal vesicles, Ultrahypofractionation

References:

[1] Parker CC, James ND, Brawley CD, Clarke NW, Hoyle AP, Ali A, et al. Radiotherapy to the primary tumour for newly diagnosed, metastatic prostate cancer (STAMPEDE): a randomised controlled phase 3 trial. Lancet. 2018;392:2353-66.

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Digital Poster

Radiotherapy or cystectomy in muscle-invasive bladder cancer: Outcomes with two clinical pathways

Priyamvada Maitre 1 , Sheetal Kashid 1 , Ajit Guleja 2 , Amandeep Arora 2 , Amit Joshi 3 , Mahendra Pal 2 , Ganesh Bakshi 2 , Santosh Menon 4 , Aparna Katdare 5 , Gagan Prakash 2 , Vedang Murthy 1 1 Tata Memorial Centre, Homi Bhabha National Institute, Radiation Oncology, Mumbai, India. 2 Tata Memorial Centre, Homi Bhabha National Institute, Surgical Oncology, Mumbai, India. 3 Tata Memorial Centre, Homi Bhabha National Institute, Medical Oncology, Mumbai, India. 4 Tata Memorial Centre, Homi Bhabha National Institute, Pathology, Mumbai, India. 5 Tata Memorial Centre, Homi Bhabha National Institute, Radiodiagnosis, Mumbai, India

Purpose/Objective:

Bladder preservation (BP) and radical cystectomy (RC) with urinary diversion are both standard treatment pathways recommended for curative treatment of muscle invasive bladder cancer (MIBC). This study assessed the oncological outcomes of patients diagnosed with MIBC treated with curative intent with either of these modalities at a tertiary care centre.

Material/Methods:

Consecutive patients with histological diagnosis of urothelial MIBC, clinical stage cT2-T4N0M0, treated with BP or RC on the basis of patient preference, comorbidities, surgical fitness, and multidisciplinary tumour board discussion at our centre were included in this ethics-approved study. Patients treated with palliative intent, or those not completing the planned treatment were excluded from this study. The primary outcome was disease-free survival (DFS), and secondary outcomes were bladder cancer-specific survival (CSS), overall survival (OS), and bladder preservation rate in patients undergoing BP. Survival outcomes were estimated with the Kaplan-Meier method, and compared between BP and RC using the log rank test.

Results: