ESTRO 2024 - Abstract Book

S2783

Interdisciplinary - Health economics & health services research

ESTRO 2024

2. Lievens Y, Borras JM, Grau C. Provision and use of radiotherapy in Europe. Mol Oncol. 2020 Jul 1;14(7):1461.

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Digital Poster

EXTREME HYPOFRACTIONATED RT FOR PROSTATE CA. Phase II. Results in toxicity and economical cost

Salvador Villa Freixa 1 , Elisa Montes 2 , Guadalupe Molina 1 , Ernest Luguera 2 , Ana Alvarez 1 , David Durany 3 , Gerard Meca 1 , Manuel Quintana 1 , Laura Alvarez 1 , Rosa Ballester 1 , Enric Moret 4 , Raquel Fernandez 1 , Silvia Comas 1 1 Catalan Institute of Oncology, Radiation Oncology, Badalona. Catalonia, Spain. 2 Catalan Institute of Oncology, Physics, Badalona. Catalonia, Spain. 3 HU Germans Trias, Radiology, Badalona. Catalonia, Spain. 4 HU Germans Trias, Anestesiology, Badalona. Catalonia, Spain

Purpose/Objective:

To analyze the feasibility and real cost in terms of early toxicity, timing, and economics in patients with prostate carcinoma treated with extreme hypofractionated radiotherapy (EHRT) (5 fractions) in a phase II trial

Material/Methods:

Patients with low and intermediate prostate carcinoma, with IPSS less than 18 and prostate volume less than 60 cc, were treated using VMAT technique with a total dose of 36.25 Gy in 5 fractions of 7.25 Gy over two and a half weeks (in 15-17 days) with 32.5 Gy total dose to PRV – urethral. VMAT techniques was used. CBCT was used pre-, during and post-fraction delivery. Fiducial markers were mandatory. Toxicity was scored using CTCAE version 5-0. Timing during radiation delivery and economic cost were also analyzed. Results were compared with moderate hypofractionated scheme (MHS) and conventional (CFRT) ones in our department.

Results:

Twenty-one consecutive patients were included (2021-2023). No patient had early GU or GI toxicity greater than grade 2. Only one patient required temporary urethral catheter. Real time at the LINAC for every fraction had a median of 20 minutes (r 15-35). The economical gain considering staff salaries (physicians, technicians, physicists, administrators, nurses), timing of machine amortization, dosimetry, fiducial markers, cost of MRI for co-registration at the same day of CT simulation, urethral catheter during CT simulation, number of visits (nurses and physicians), transportation of patients to the center, and other fungible materials was clearly beneficial for extreme EHRT (1608 euros for CFRT vs. 2746 euros for MHS vs. 3550 euros for EHRT) considering the global payment for VMAT RT from the Catalan Health System

Conclusion: