ESTRO 2024 - Abstract Book

S2883

Interdiscplinary - Other

ESTRO 2024

an increase in the production of reactive oxygen species (ROS) is observed, the more substantial enhancement is seen in radial dose. In contrast, when AuNPs are combined with protons, a remarkable increase in ROS production is evident, highlighting the prominent role of the chemical mechanism over the physical one.

Keywords: Nanoparticles, Radiosensitization, Monte Carlo

References:

[1] Kuncic, Zdenka, and Sandrine Lacombe. "Nanoparticle radio-enhancement: principles, progress and application to cancer treatment." Physics in Medicine & Biology 63.2 (2018): 02TR01.

[2] Perl, Joseph, et al. "TOPAS: an innovative proton Monte Carlo platform for research and clinical applications." Medical physics 39.11 (2012): 6818-6837.

[3] Schuemann, J., et al. "TOPAS-nBio: an extension to the TOPAS simulation toolkit for cellular and sub-cellular radiobiology." Radiation research 191.2 (2019): 125-138.

[4] Khoshgard, Karim, et al. "Radiosensitization effect of folate-conjugated gold nanoparticles on HeLa cancer cells under orthovoltage superficial radiotherapy techniques." Physics in Medicine & Biology 59.9 (2014): 2249.

[5] Rudek, Benedikt, et al. "Radio-enhancement by gold nanoparticles and their impact on water radiolysis for x ray, proton and carbon-ion beams." Physics in Medicine & Biology 64.17 (2019): 175005.

582

Digital Poster

Determining Filipino breast cancer patients' health-related quality of life using the EQ-5D-5L tool

Harroun T Wong 1 , Kurl E Jamora 1 , Analigaya R Agoncillo-Infante 2 , Florge A Sy 2 , Kathleen H Baldivia 1

1 Philippine General Hospital, Department of Radiology, Manila, Philippines. 2 Philippine General Hospital, Department of Medicine, Manila, Philippines

Purpose/Objective:

Attaining good quality of life for breast cancer patients is more important now as part of cancer care as survival outcomes have markedly improved. We measured the health-related quality of life (HRQoL) and factors affecting it among breast cancer patients at the Philippine General Hospital. Breast cancer patient characteristics seen at the out-patient clinics were described and an estimate of their health utility scores, based on their disease management status, was obtained using the 5-level EuroQol 5-dimension (EQ-5D-5L) health status measurement tool. The association between the EQ-5D-5L scores and patient demographic, disease, and treatment characteristics were also investigated. EQ-5D-5L data were converted to health state utility values (HSUV). The generation of HSUV data for different stages and health states of breast cancer patients can provide us with more meaningful outcomes. It can be used to estimate quality-adjusted life-years (QUALYs) for any clinically relevant time-based outcome such as progression-free survival (PFS), distant metastasis-free survival (DMFS), and overall