ESTRO 2024 - Abstract Book

S2892

Interdiscplinary - Other

ESTRO 2024

Results:

Ninety-eight patients with a total of 114 lung lesions (87 peripheral and 27 central) were treated. Median age was 79 years (range 52-92) and 36 patients were females (Table 1). Median PTV was 14.3 cc (range 3.5-83.0). In three out of 114 SABR treatments, an early-time CTs was not performed. Eighty-six and 61 follow up CT scans in the mid-term and in the long-term period have been obtained, respectively. At these timepoints, 9 and 13 lesions developed a local relapse. At early-term period, diffuse consolidation was the most represented pattern in the lower lobes (52.4%), while patchy consolidation (52.2%), diffuse ground glass opacity (GGO) (77.8%) and patchy GGO (72.7%) patterns were mostly identified in the upper lobes (p=0.281). At mid-term period, 64% of the lesions that have resulted in a modified convention pattern were related to previous lung surgery (p=0.001). Lower lobes lesions evolved in a modified conventional pattern in 54% of the cases, while 52% of mass like and 75% of scar like patterns were found in the upper lobes (p=0.194).

After one year (long-term period) 62.5% of radiation-induced lung injuries (with no distinction between late radiological patterns) incurred in the upper lobes (p=0.227).

Significant correlations or trends between radiological patterns and evaluated dose metrics were not found. Specific radiological findings are reported in Table 2.