ESTRO 2024 - Abstract Book

S314

Brachytherapy - Head & neck, skin, eye

ESTRO 2024

SMBT was successfully planned and delivered for EMPD using 3D printed custom applicators. Excellent target coverage was achieved while minimizing dose to organs at risk and toxicity and cosmesis rates were good to excellent. All patients achiever complete response and surface mould brachytherapy is an excellent alternative treatment modality for EMPD patients.

Keywords: Extramammary Paget's disease, Brachytherapy

2131

Digital Poster

Nanoparticle-assisted brachytherapy in eye melanoma tumor: a concept analysis

Samaneh Hashemi 1 , Seyed Mahmoud-Reza Aghamiri 1 , Zahra Siavashpour 2 , Mahdi Kahani 1 , Habib Zaidi 3 , Ramin Jaberi 4,5 1 Shahid Beheshti University, Medical Radiation, Tehran, Iran, Islamic Republic of. 2 Shahid Beheshti University of Medical Sciences, Radiotherapy Oncology, Tehran, Iran, Islamic Republic of. 3 Geneva University, Geneva University Neurocenter, Geneva, Switzerland. 4 Tehran University of Medical Sciences, Cancer Research Center, Tehran, Iran, Islamic Republic of. 5 Surrey University, Medical Physics Department, Guilford, United Kingdom

Purpose/Objective:

Nanoparticles (NPs) have long been researched for use in treating eye diseases such as melanoma due to their ability to pass biological barriers that prevent foreign substances from accessing the ocular environment (1,2). Brachytherapy via Ruthenium-106 (106Ru) ocular plaques has been employed for decades to manage ocular melanoma, with the applicator put on the patient's eyes until the required dose achieves the tumor apex (3,4). This placement can cost hospital-hosting of the patient for days and exceed the dose of superficial layers. This work intends to investigate a suitable radio-sensitive particle to optimize the 106Ru dose distribution in a melanoma environment based on the physics of the particle's interactions.

Material/Methods: