ESTRO 2024 - Abstract Book

S315

Brachytherapy - Head & neck, skin, eye

ESTRO 2024

This research combines both simulation and experiments to investigate the use of hydrogen nanobubbles (H2 NBs) as an electron dose enhancer in brachytherapy for ocular cancer. The MCNPX Monte Carlo (MC) method mimicked the complete eyeball, including the sclera, choroid, lens, cornea, optic nerve, and tumor. In the initial stage, all the phantom simulations were filled with water. At the second step, 100-nm-diameter H2-NBs were simulated inside tumor tissue at different concentrations. The findings showed up as the dose enhancement factor in percent (DEF%) and deposited energy. Thermoluminescence dosimetry and a unique phantom were used to evaluate the simulation findings. Using 3D printers and AutoCAD, a resin phantom of the human eye was developed. Seven glass beads of 1.2 mm in height were arranged in a row along the center axis of the plaque within the tumor volume. Likewise, three glass bead strands were inserted into each of the three cylindrical holes located at the rear of the pseudotumor cell. Dose data was driven under the circumstances of pure water and 1% hydrogen-enriched water as tumor material, respectively. Figure 1 shows both the simulation and experimental setup for this research.

Results: