ESTRO 2024 - Abstract Book

S3898

Physics - Image acquisition and processing

ESTRO 2024

Conclusion:

This dynamic phantom demonstrates the capability for quantitative comparison of DCE-MRI protocols to aid in the standardization of DCE-MRI. This novel approach using a motion phantom has potential for testing of innovative sequences and for multicentre clinical trial credentialling to support larger scale trials with DCE-MRI biomarkers.

Keywords: Quantitative MRI, DCE MRI,

References:

[1] Tofts PS, Brix G, Buckley DL, et al. Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: standardized quantities and symbols. J Magn Reson Imaging 1999;10:223-32.

[2] Amita Shukla-Dave, Nancy A Obuchowski , Thomas L Chenevert , et al. Quantitative imaging biomarkers alliance (QIBA) recommendations for improved precision of DWI and DCE-MRI derived biomarkers in multicenter oncology trials, Amita Shukla-Dave, J Magn Reson Imaging 2019 Jun;49(7):e101-e121

[3] Melanie Freed et al. Development and characterization of a dynamic lesion phantom for the quantitative evaluation of dynamic contrast-enhanced MRI Med. Phys. 2011; 38 (10)

[4] Driscoll B, Keller H, Coolens C. Development of a dynamic flow imaging phantom for dynamic contrast-enhanced CT. Med Phys 2011;38(8):4866–4880

[5] Harrison Kim et al. Portable perfusion phantom for quantitative DCE-MRI of the abdomen Med. Phys. 2017; 44 (10)

2179

Digital Poster

Clinical evaluation of deep learning based synthetic CTs from CBCTs for head-and-neck proton therapy

Casper D. Vestergaard 1 , Ulrik V. Elstrøm 1 , Ludvig P. Muren 1 , Jintao Ren 1 , Ole Nørrevang 1 , Kenneth Jensen 1 , Vicki T. Taasti 1,2 1 Aarhus University Hospital, Danish Centre for Particle Therapy, Aarhus, Denmark. 2 Maastricht University Medical Center+, Department of Radiation Oncology (MAASTRO), Maastricht, Netherlands

Purpose/Objective:

Anatomical variations are frequently seen during the treatment course of proton therapy for head-and-neck cancer patients. The impact of these anatomical changes with respect to target coverage and normal tissue sparing needs to