ESTRO 2024 - Abstract Book

S4293

Physics - Intra-fraction motion management and real-time adaptive radiotherapy

ESTRO 2024

1835

Digital Poster

4D Particle Therapy Workshop: Multi-clinic comparison of 4D treatment approaches for a lymphoma case

Katarzyna Czerska 1 , Francesca Albertini 1 , Nicolas Depauw 2 , Giovanni Fattori 1 , Rachel Hunter 3 , Minglei Kang 4 , Barbara Knäusl 5 , Katarzyna Krzempek 6 , Stefano Lorentini 7 , Hanna Rahbek Mortensen 8 , Abdallah Qubala 9,10,11 , Ilaria Rinaldi 12 , Marco Schwarz 13 , Line Bjerregaard Stick 8 , Kristin Stützer 14,15 , Masaaki Takashina 16 , Eva van Weerd 17 , Marije Velders 12 , Ye Zhang 1 , Jan Hrbacek 1 1 Paul Scherrer Institute, Center for Proton Therapy, Villigen PSI, Switzerland. 2 Massachusetts General Hospital and Harvard Medical School, Department of Radiation Oncology, Boston, MA, USA. 3 The University of Texas MD Anderson Cancer Center, Department of Radiation Physics, Division of Radiation Oncology, Houston, TX, USA. 4 New York Proton Center, -, New York, NY, USA. 5 Medical University of Vienna, Department of Radiation Oncology, Vienna, Austria. 6 Institute of Nuclear Physics Polish Academy of Sciences, -, PL-31-342 Krakow, Poland. 7 Azienda Provinciale per i Servizi Sanitari (APSS), Medical Physics Department, Trento, Italy. 8 Aarhus University Hospital, Danish Centre for Particle Therapy, Aarhus, Denmark. 9 Heidelberg Ion Beam Therapy Center (HIT), -, Heidelberg, Germany. 10 University of Heidelberg, Faculty of Medicine, Heidelberg, Germany. 11 Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany. 12 Maastricht University Medical Centre+, Department of Radiation Oncology (Maastro), GROW School for Oncology, Maastricht, Netherlands. 13 University of Washington & Fred Hutchinson Cancer Center, Radiation Oncology Department, Seattle, CA, USA. 14 OncoRay – National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. 15 Helmholtz-Zentrum Dresden - Rossendorf, Institute of Radiooncology – OncoRay, Dresden, Germany. 16 Osaka Heavy Ion Therapy Center, Department of Medical Physics, Osaka-shi, Osaka, Japan. 17 HollandPTC, -, Delft, Netherlands

Purpose/Objective:

The 2023 4D Particle Therapy Workshop organized a multi-institutional questionnaire treatment planning study aiming at comparing the differences in clinically applied 4D techniques across various institutions as an undertaking towards harmonizing 4D treatment approaches in particle therapy. Based on these, variabilities between treatment planning and delivery approaches have been assessed. The initial findings from the questionnaires’ and preliminary analysis of the multi-institutional planning study are presented.

Material/Methods:

The clinical 4D indication, considered a moving target and selected for this study, was a primary mediastinal B-cell lymphoma. The shared dataset included imaging data (4DCT, gated CT, average CT), structure sets (targets, organs at risk (OARs)), prescription details and breathing motion signal acquired during imaging dedicated to treatment planning. Participating institutions were asked to assess the motion amplitude and perform treatment planning according to the evaluated motion and based on their own internal protocols. In addition, two questionnaires were distributed, covering both general and case-specific information to provide a comprehensive understanding of the workflow steps used.