ESTRO 2024 - Abstract Book

S4553

Physics - Machine learning models and clinical applications

ESTRO 2024

We will include the obtained relationship in a computational model to predict variations in the microcirculation state after irradiation and for different patient-specific scenarios. As a possible extension, we will use it to describe the variation of oxygen distribution within the tumour microenvironment, merging it with evaluating the importance of the microvessel net morphology in the tumour, which highly affects the baseline haemoglobin concentration. This helps develop mechanistic models of tumour cell death after radiotherapy and tumour regression.

Keywords: RT damage, microcirculation study, in-silico model

References:

1) J. O. Archambeau, et al, Pathophysiology of irradiated skin and breast. International Journal of Radiation Oncology* Biology* Physics, 31(5):1171–1185, 1995.

2) Secomb, T. w. (2016). A Green’s function method for simulation of time-dependent solute transport and reaction in realistic microvascular geometries. Mathematical Medicine and Biology, 33(4), 475–494. https://doi.org/10.1093/imammb/dqv031

3) Luca Possenti et al., Ann Biomed Eng 49 2021, doi: https://doi.org/10.1007/s10439-021-02807-x

4) Alessandro Cicchetti et al., European Journal of medical physics, 2020, doi: https://doi.org/10.1016/j.ejmp.2020.04

5) GN Stamatas et al., British Journal of Dermatology 159.3, 2008, doi: https://doi.org/10.1111/j.1365 2133.2008.08642.x.

6) Microvascular morphology affects radiotherapy outcomes: a computational study Luca Possenti, Piermario Vitullo, Alessandro Cicchetti, Paolo Zunino, Tiziana Rancati, bioRxiv 2023.10.16.562646; doi: https://doi.org/10.1101/2023.10.16.562646

Acknowledgments This work was supported by the AIRC Investigator Grant, no. IG21479.

2692

Digital Poster

Modelling lymphocyte counts of NSCLC patients during chemoradiotherapy for survival analysis.

Celia Juan-Cruz, Barbara Stam, Maddalena Rossi, José Belderbos, Jan-Jakob Sonke

The Netherlands Cancer Institute, Radiation Oncology, Amsterdam, Netherlands

Purpose/Objective: