ESTRO 2024 - Abstract Book

S455

Clinical - Breast

ESTRO 2024

220

Digital Poster

Impact of hypofractionated PMRT on the health-related QoL of Filipino breast cancer patients

Kurl E Jamora 1,2 , Ella Mae DG Cruz-Lim 1 , Reno Eufemon P Cereno 1 , Michelle Regina L Castillo 1 , Aedrian Abrilla 3 , Kathleen H Baldivia 1 1 Philippine General Hospital, Department of Radiology, Division of Radiation Oncology, Manila, Philippines. 2 Princess Margaret Cancer Centre, Department of Radiation Oncology, Toronto, Canada. 3 University of the Philippines-Manila, College of Medicine, Manila, Philippines

Purpose/Objective:

The aim of this study was to assess the impact of radiotherapy in the quality of life (QoL) of breast cancer patients who underwent hypofractionated postmastectomy radiotherapy (PMRT) and to identify factors that influence their QoL.

Material/Methods:

The Tagalog versions of the EORTC QLQ C-30 and BR-45 questionnaires were used to evaluate the changes in the QoL of 93 women at the start of RT, at completion of RT, and two weeks and three months post-RT.

Results:

Global health scores indicating QoL were generally high, but there was a significant decline in QOL two weeks post RT (69.30 ± 21) compared to baseline (76.99 ± 19). However, this showed an improvement three months after treatment (72.86 ± 21). Functional scales were consistently high and did not exhibit significant changes across the measured time points. Nausea and vomiting, pain, and appetite loss increased during RT but resolved three months after treatment. Financial difficulties and future perspective also significantly improved at three months post-RT compared to baseline. Breast satisfaction declined at completion of RT (from 67.82 ± 23.82 to 53.52 ± 25.96), and at two weeks (49.56 ± 26.38) and three months (53.73 ± 27.30) post-RT. Systemic therapy side effects and upset by hair loss were also reduced at three months post-RT compared to baseline. Breast symptoms worsened significantly at completion of RT (20.95 ± 17.30) and two weeks post-RT (29.98 ± 17.54) than at baseline (14.20 ± 13.20); however, these returned to baseline levels three months post-RT (16.35 ± 17.01).

Table 1. Comparison of EORTC QLQ-C30 and BR45 questionnaire scores at four time points