ESTRO 2024 - Abstract Book

S4805

Physics - Quality assurance and auditing

ESTRO 2024

Material/Methods:

This is an overview of trials published in PubMed between 1988 and 2022 which performed and published their RTQA results. A search was also performed on the ClinicalTrials.gov database to find the actual number of clinical trials using radiotherapy as treatment. Naming conventions were those defined by the GHG work. In brief, benchmark cases were defined as full RT planning or delineation test in one common CT scan, and Dummy run as a similar process on an in-house patient. Individual case reviews were reviews of the actual treatment plans of trial patients. Characteristics of clinical trials and propensity to conduct RTQA were overviewed over time. The trends toward more systematic and prospective RTQA were assessed.

Figure 1 Flowchart identifying trials that performed and published RTQA

Results:

Of the 663 articles found on PubMed, 130 studies were selected as conducting RTQA between 1988 and 2022 (Figure 1). Of these studies, 96 trials published qualitative or quantitative analyses. During the same period, compared to registered trials on the Clinicaltrials.gov database, 1.15% and 0.85% of trials performed and published RTQA respectively with no significant trend over time (Figure 2). Seventy-three trials (58%) performed a benchmark case (BC) or dummy run (DR), 93 (73.8%) an individual case review and 24 (18.9%) an end-to-end audit. Most of the studies were performed in Europe (n= 58, 44.6%), followed by the US (n= 25, 19.2%). A higher proportion of prospective RTQA