ESTRO 2024 - Abstract Book

S4806

Physics - Quality assurance and auditing

ESTRO 2024

was found over time (BC/DR: 33.3% during 1988-1999 vs 100% during 2016-2022; ICR: 16.7% in 1988-1999 vs 50% in 2016-2022). Considering BC/DR, credentialing procedures increased from 33.3% (1988-1999) to 86.7% (2016-2022). A decrease in the number of ICR planned in the studies’ protocols was observed over time, notably with a decrease in the number of trials requiring an ICR for all patients, from 75% to 50% in the periods 1988-1999 and 2016-2022 respectively.

Figure 2: Evolution in RTQA procedures over time. Proportion of trials which performed RTQA based on the number of clinical trials registered in ClinicalTrials.gov.

Conclusion:

RT quality assurance is important for ensuring the RT plan’s quality in clinical trials. This study highlights the small number of trials performing RTQA, and even fewer publishing results. No significant increase over time was found, while progress in RT techniques is constant. However, more complete RTQA procedures were shown over time. Many kinds of RTQA were recorded, with no harmonization between tools and analyses. Types of RTQA vary substantially over time and more analysis should be performed to assess the most adequate and reliable RT plan quality assurance.

Keywords: RTQA, benchmark case, individual case review

References:

Ohri N, Shen X, Dicker AP, Doyle LA, Harrison AS, Showalter TN. Radiotherapy Protocol Deviations and Clinical Outcomes: A Meta-analysis of Cooperative Group Clinical Trials. JNCI Journal of the National Cancer Institute. 2013 Mar 20;105(6):387–93. Peters LJ, O’Sullivan B, Giralt J, Fitzgerald TJ, Trotti A, Bernier J, et al. Critical Impact of Radiotherapy Protocol Compliance and Quality in the Treatment of Advanced Head and Neck Cancer: Results From TROG 02.02. JCO. 2010 Jun 20;28(18):2996–3001.

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