ESTRO 2024 - Abstract Book

S4976

Physics - Radiomics, functional and biological imaging and outcome prediction

ESTRO 2024

References:

Acknowledgements: German Center for Lung Research (DZL)

1. Klaar R, Rabe M, Gaass T, et al. Ventilation and perfusion MRI at a 0.35 T MR-Linac: feasibility and reproducibility study. Radiat Oncol . 2023;18(1):58.

2. Käsmann L, Dietrich A, Staab-Weijnitz CA, et al. Radiation-induced lung toxicity - cellular and molecular mechanisms of pathogenesis, management, and literature review. Radiat Oncol. 2020;15(1):214.

3. Kimura T, Doi Y, Nakashima T, et al. Combined Ventilation and Perfusion Imaging Correlates With the Dosimetric Parameters of Radiation Pneumonitis in Radiation Therapy Planning for Lung Cancer. Int J Radiat Oncol Biol Phys. 2015;93(4):778-787.

4. Katsuta Y, Kadoya N, Kajikawa T, et al. Radiation pneumonitis prediction model with integrating multiple dose function features on 4DCT ventilation images. Phys Med. 2023;105:102505.

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Digital Poster

Clinical, dosimetric and radiomics features predictive of lung toxicity after (chemo)radiotherapy

Cécile Evin 1,2 , Léo Razakamanantsoa 3 , François Gardavaud 4,5 , Léa Papillon 6 , Hamza Boulaala 6 , Loïc Ferrer 6 , Olivier Gallinato 6 , Thierry Colin 6 , Sondos Ben Moussa 7,1,2 , Yara Harfouch 8,1,2 , Jean-Noël Foulquier 4 , Sophie Guillerm 9 , Jean Emmanuel Bibault 10 , Florence Huguet 1 , Mathilde Wagner 11,2 , Eleonor Rivin del Campo 1,2 1 Hôpital Tenon, Oncologie Radiothérapie, Paris, France. 2 Sorbonne Université, Laboratoire d’Imagerie Biomédicale UMR 7371 - U1146, Paris, France. 3 Hôpital Tenon, Imageries Radiologiques et Interventionnelles Spécialisées (IRIS), Paris, France. 4 Hôpital Tenon, Physique médicale, Paris, France. 5 Sorbonne Université, Institut des sciences de calcul et des données ISCD d’Imagerie Biomédicale UMR 7371 - U1146, Paris, France. 6 SOPHiA GENETICS, Radiomics research, Pessac, France. 7 Université de Tours, Faculté de médecine, Tours, France. 8 Université de Grenoble, Faculté de médecine, Grenoble, France. 9 Hôpital Saint-Louis, Oncologie Radiothérapie, Paris, France. 10 Hôpital Européen Georges Pompidou, Oncologie Radiothérapie, Paris, France. 11 Hôpital Pitié-Salpêtrière, Radiologie, Paris, France

Purpose/Objective:

Treatment of locally advanced non small cell lung cancer is based on chemoradiotherapy, which may cause acute lung toxicity: radiation pneumonitis (RP). Its frequency is increased by the use of adjuvant durvalumab therapy.

The objective of this study was to identify clinical, dosimetric, and radiomics factors associated with grade (G) ≥ 2 RP (CTCAE v6.0), to conduct an explanatory analysis, and to construct a prediction model based on selected parameters.