ESTRO 2024 - Abstract Book

S5014

Physics - Radiomics, functional and biological imaging and outcome prediction

ESTRO 2024

Conclusion:

This study demonstrated variation in dosimetric predictors of the RIL based on the timing of evaluation. From RT start to 1 week post-RT, the significance of low-dose radiation to lungs, body in addition to thoracic vertebral body implies that early RIL results from radiation exposure to circulating lymphocytes. Conversely, after 1 week post RT, thoracic vertebral body was the only OAR with the relevant dose level higher than those up to 1 week post RT. This might suggest that other than damage to circulating lymphocytes plays a critical role in RIL after RT. Despite the limitations of a retrospective study with a limited sample size, our findings might offer valuable insights into the dynamic mechanism of lymphocyte counts. Furthermore, these findings underscore the importance of considering the timing of RIL evaluations for more accurate predictions and effective mitigation strategies, which could be crucial in the emerging consolidative immunotherapy setting.

Keywords: radiation-induced lymphopenia, NSCLC, NTCP

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