ESTRO 2024 - Abstract Book

S5071

Physics - Radiomics, functional and biological imaging and outcome prediction

ESTRO 2024

Keywords: radiomics, imaging biomarkers, radioresistance

References:

1. Gorphe P, Classe M, Ammari S, Garcia G, Even C, Casiraghi O, Breuskin I, Tao Y, Temam S, Blanchard P, Moya-Plana A. Patterns of disease events and causes of death in patients with HPV-positive versus HPV-negative oropharyngeal carcinoma. Radiother Oncol. 2022 Mar;168:40-45. 2. Asheer J, Jensen JS, Grønhøj C , Jakobsen KK, von Buchwald C. Rate of locoregional recurrence among patients with oropharyngeal squamous cell carcinoma with known HPV status: a systematic review, Acta Oncologica 2020 59:9, 1131-1136 3. Paterson C, Allwood-Spiers S, McCrea I, Foster J, McJury M, Thomson M, Sankaralingam M, Grose D, James A, Rizwanullah M, McLoone P, Chalmers A, Duffton A. Study of diffusion weighted MRI as a predictive biomarker of response during radiotherapy for high and intermediate risk squamous cell cancer of the oropharynx: The MeRInO study. Clin Transl Radiat Oncol. 2017 Jan 10;2:13-18. 4. van Griethuysen JJM, Fedorov A, Parmar C, Hosny A, Aucoin N, Narayan V, Beets-Tan RGH, Fillon-Robin JC, Pieper S, Aerts HJWL. Computational Radiomics System to Decode the Radiographic Phenotype. Cancer Research. 2017 77;21: e104–e107.

5. R Core Team (2023). R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing, Vienna, Austria.

1676

Digital Poster

Unexpected correlation between DWI and treatment response in HPV negative oropharyngeal carcinoma

Iris Lauwers 1 , Nienke D. Sijtsema 1,2 , Marta E. Capala 1 , Mischa S. Hoogeman 1,3 , Dirk H.J. Poot 4 , Juan A. Hernandez Tamames 4 , Aad van der Lugt 4 , Gerda M. Verduijn 1 , Steven F. Petit 1 1 Erasmus Medical Center, Department of Radiotherapy, Rotterdam, Netherlands. 2 Erasmus Medical Center, Department of Radiology and Nuclear Medicine, RotterdaDepartment of Radiology and Nuclear Medicinem, Netherlands. 3 HollandPTC, Department of Medical Physics and Informatics, Delft, Netherlands. 4 Erasmus Medical Center, Department of Radiology and Nuclear Medicine, Rotterdam, Netherlands

Purpose/Objective:

Diffusion-weighted imaging (DWI) is a promising technique for (chemo-)radiotherapy response assessment in head and neck cancer. Conventionally, the ADC DWI model was most widely used DWI model; however, the ADC model assesses only the apparent extracellular diffusion ( ADC ). Currently, more extensive models are available, such as the