ESTRO 2024 - Abstract Book


Clinical - Breast

ESTRO 2024

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Stereotactic Partial Breast Irradiation: 4-year Clinical Results and Cosmetic Outcomes

Norbert Meszaros 1,2 , Levente Janvary 1 , Viktor Smanyko 1 , Tibor Major 1,2 , Gabor Stelczer 1 , Zoltan Nagy Takacsi 1,2 , Csaba Polgar 1,2 1 National Institute of Oncology, Center of Radiotherapy, Budapest, Hungary. 2 Semmelweis University, Faculty of Medicine, Department of Oncology, Budapest, Hungary


The aim of this study was to evaluate the clinical results and cosmetic outcomes of 4-fraction stereotactic accelerated partial breast irradiation (SAPBI).


Between November 2018 and November 2022, 71 patients with low risk early invasive (St I-II) breast cancer underwent BCS were enrolled in our phase II prospective study. SAPBI was performed with Cyber-Knife (CK) M6 machine, to a total dose of 25 Gy (4 x 6.25 Gy, delivered daily). Respiratory movements were followed with implanted gold markers and optical markers using Synchrony system. Corrections for patient displacement and respiratory movement during treatment were performed with the robotic arm. Clinical results, side effects, and cosmetic results were assessed.


In all patients, the treatments were successfully completed, and the dose prescriptions and dose limits were observed. Median follow-up time was 48 months (range:11-60 months). During the follow-up, we did not detect any local or regional recurrence or distant metastases. Acute side effects included Grade 1 (G1) erythema, which occurred in 8 (11.2%) patients, while G1 oedema was observed in 7 (9.8%) cases. G1 pain was reported by 1 (1.4 %) patient. Late side effects included G1 fibrosis in 11 (15.5%), G1 pain in 4 (5.6%) patients respectively. Asymptomatic

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