ESTRO 2024 - Abstract Book

S5226

Radiobiology - Microenvironment

ESTRO 2024

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Acknowledgments

This work was supported by the AIRC Investigator Grant, no. IG21479.

2847

Proffered Paper

Regulatory role of miRNAs at different tumor hypoxia levels in prostate cancer patients

Vilde Eide Skingen 1,2 , Unn Beate Salberg 1,3 , Christina S Fjeldbo 1 , Tord Hompland 1 , Kari-Anne M Frikstad 1 , Harald B Ragnum 4 , Ljiljana Vlatkovic 5 , Knut Håkon Hole 6,3 , Therese Seierstad 6 , Heidi Lyng 7 1 Insitute for Cancer Research, Department of Radiation Biology, Oslo, Norway. 2 University of Oslo, Department of Physics, Oslo, Norway. 3 University of Oslo, Institute of Clinical Medicine, Oslo, Norway. 4 Telemark Hospital Trust, Department of Haematology and Oncology, Skien, Norway. 5 Oslo University Hospital, Department of Pathology, Oslo, Norway. 6 Oslo University Hospital, Division of Radiology and Nuclear Medicine, Oslo, Norway. 7 Oslo University Hospital, Department of Radiation Biology, Oslo, Norway

Purpose/Objective:

Tumor hypoxia is associated with prostate cancer aggressiveness and reduced radiotherapy efficacy. Cancer cells adapt to hypoxia by modifying their gene expression. The underlying regulatory mechanisms seem to depend on hypoxia level, but this remains largely unexplored in patient tumors where the assessment of hypoxia levels is challenging. Gaining a deeper understanding of these mechanisms could lead to novel therapeutic approaches. MiRNAs are essential in governing gene expression programs by downregulating genes, thereby influencing various cellular processes. Here, we aimed to determine the regulatory role of miRNAs at different hypoxia levels in prostate cancer by integrating miRNA and gene expression with spatial histopathology in biopsies from patient tumors.