ESTRO 2024 - Abstract Book

S5256

Radiobiology - Normal tissue radiobiology

ESTRO 2024

Fig.2 shows a summary of novel object recognition data at all timepoints. At baseline, all groups showed significant preference for the novel object, as well as a positive DI (Fig.2). Whereas control mice continued to show a statistically significant preference for the novel object at all time points (Fig.2): this preference was not observed in irradiated mice at any time point post-RT (Fig.2). In the group given olaparib, the novel object was preferred at 1 month (P<0.001), 2 months (P<0.001), and 6 months (P<0.01). In the group given pamiparib, the novel object was preferred at 1 month (P<0.0001). Dunnett's multiple comparisons were used to compare each treatment to its baseline DI. The RT group was significantly different from baseline in all cases apart from month 2 (p=0.0775). The PARP inhibitor treatments reversed the observed RT deficit at all timepoints apart from in the pamiparib group in month 3 (P<0.05). These results indicate that brain irradiation significantly impairs recognition memory, a deficit that is reduced by administration of either olaparib or pamiparib immediately prior to irradiation and for 1 week post-irradiation.