ESTRO 2024 - Abstract Book

S5257

Radiobiology - Normal tissue radiobiology

ESTRO 2024

Conclusion:

Our results indicate that we can track inflammatory and cognitive changes post-RT in mice using PET imaging and novel object recognition testing. We have shown that PARP inhibition reduces radiation-induced neuroinflammation and has a beneficial effect on recognition memory, post-radiotherapy.

Keywords: PET Imagng, Behaviour, Mice

References:

1. Sheline, G.E., W.M. Wara, and V. Smith, Therapeutic irradiation and brain injury. Int J Radiat Oncol Biol Phys, 1980. 6(9): p. 1215-28.

2. Greene-Schloesser, D., E. Moore, and M.E. Robbins, Molecular pathways: radiation-induced cognitive impairment. Clin Cancer Res, 2013. 19(9): p. 2294-300.

3. Makale, M.T., et al., Mechanisms of radiotherapy-associated cognitive disability in patients with brain tumours. Nat Rev Neurol, 2017. 13(1): p. 52-64.

4. Monje, M.L., H. Toda, and T.D. Palmer, Inflammatory blockade restores adult hippocampal neurogenesis. Science, 2003. 302(5651): p. 1760-5.

5. Rola, R., et al., Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice. Exp Neurol, 2004. 188(2): p. 316-30.