ESTRO 2024 - Abstract Book

S5299 2801

Radiobiology - Normal tissue radiobiology

ESTRO 2024

Digital Poster

Establishing a UK photon FLASH Radiotherapy Facility (FLASH-SARRP)

Karl T Butterworth, Kevin M Prise, Kathryn H Brown, Mihaela Ghita, Stephen J McMahon

Queen's University Belfast, Patrick G Johnston Centre for Camcer Research, Belfast, United Kingdom

Purpose/Objective:

Photon flash radiotherapy (FLASH) has emerged as a promising technique for cancer treatment due to its potential to spare normal tissues while effectively damaging tumor cells. To further investigate the biological effects and underlying radiobiological mechanisms of photon FLASH, there is a need for a dedicated experimental beamline using state-of-the-art photon technology. The primary objectives of this study are to establish a UK photon FLASH radiotherapy facility and investigate the biological effects of flash radiotherapy using photon beams on various normal tissue and tumor models. Additionally, the study aims to explore the radiobiological mechanisms of photon FLASH.

Material/Methods:

The proposed experimental beamline will utilize advanced photon technology to deliver high-energy photon beams. The system will provide the necessary beam characteristics required for conducting comprehensive investigations into the effects of photon FLASH on normal tissues and tumors.

Results:

The establishment of the FLASH-SARRP (Flash Small Animal Radiotherapy Research Platform) will provide a unique and dedicated platform for the development of novel FLASH protocols using photons. The data obtained from experiments conducted at this facility will contribute to the ongoing optimization of treatment parameters, fractionation schemes, and treatment delivery techniques for potential clinical translation.

Conclusion:

By establishing this dedicated experimental beamline, the flash radiotherapy community will gain access to a unique platform for conducting comprehensive investigations into the potential benefits and challenges of photon FLASH. These studies will pave the way for future clinical implementation of flash radiotherapy, ultimately leading to improved cancer treatment outcomes and enhanced patient care.

Keywords: FLASH, preclincial models, photons

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