ESTRO 2024 - Abstract Book
S5344
Radiobiology - Tumour biology
ESTRO 2024
1. Böttger F, Vallés-Martí A, Cahn L, Jimenez CR. High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer. J Exp Clin Cancer Res. 2021 Dec;40(1):343. 2. Ma Y, Chapman J, Levine M, Polireddy K, Drisko J, Chen Q. High-dose parenteral ascorbate enhanced chemosensitivity of ovarian cancer and reduced toxicity of chemotherapy. Sci Transl Med. 2014 Feb 5;6(222):222ra18. 3. Buranasudja V, Doskey CM, Gibson AR, Wagner BA, Du J, Gordon DJ, et al. Pharmacologic Ascorbate Primes Pancreatic Cancer Cells for Death by Rewiring Cellular Energetics and Inducing DNA Damage. Mol Cancer Res. 2019 Oct 1;17(10):2102–14. 4. Chiu SM, Xue LY, Friedman LR, Oleinick NL. Differential dependence on chromatin structure for copper and iron ion induction of DNA double-strand breaks. Biochemistry. 1995 Feb 28;34(8):2653–61. 5. Ghanem A, Melzer AM, Zaal E, Neises L, Baltissen D, Matar O, et al. Ascorbate kills breast cancer cells by rewiring metabolism via redox imbalance and energy crisis. Free Radic Biol Med. 2021 Feb 1;163:196–209. 6. Mehdi Z, Petronek MS, Stolwijk JM, Mapuskar KA, Kalen AL, Buettner GR, et al. Utilization of Pharmacological Ascorbate to Enhance Hydrogen Peroxide-Mediated Radiosensitivity in Cancer Therapy. Int J Mol Sci. 2021 Oct 8;22(19):10880. 7. Reynolds M, Stoddard L, Bespalov I, Zhitkovich A. Ascorbate acts as a highly potent inducer of chromate mutagenesis and clastogenesis: linkage to DNA breaks in G 2 phase by mismatch repair. Nucleic Acids Res. 2007 Jan 15;35(2):465–76. 8. Sinha BK, van ‘t Erve TJ, Kumar A, Bortner CD, Motten AG, Mason RP. Synergistic Enhancement of Topotecan Induced Cell Death by Ascorbic Acid in Human Breast MCF-7 Tumor Cells. Free Radic Biol Med. 2017 Dec;113:406–12. 9. Ma Y, Chen P, Drisko JA, Khabele D, Godwin AK, Chen Q. Pharmacological ascorbate induces “BRCAness” and enhances the effects of Poly(ADP-Ribose) polymerase inhibitors against BRCA1/2 wild-type ovarian cancer. Oncol Lett. 2020 Apr;19(4):2629–38. 10. O’Connor MJ. Targeting the DNA Damage Response in Cancer. Mol Cell. 2015 Nov;60(4):547–60. 11. Olivieri M, Cho T, Álvarez-Quilón A, Li K, Schellenberg MJ, Zimmermann M, et al. A Genetic Map of the Response to DNA Damage in Human Cells. Cell. 2020 Jul 23;182(2):481-496.e21. 12. Shibata A, Jeggo P, Löbrich M. The pendulum of the Ku-Ku clock. DNA Repair. 2018 Nov 1;71:164–71. 13. Ciccia A, Elledge SJ. The DNA damage response: making it safe to play with knives. Mol Cell. 2010 Oct 22;40(2):179–204. 14. Jette N, Lees-Miller SP. The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosis. Prog Biophys Mol Biol. 2015 Mar 1;117(2):194–205. 15. Han J, Huang J. DNA double-strand break repair pathway choice: the fork in the road. Genome Instab Dis. 2020 Jan 1;1(1):10–9. 16. Gustafsson AS, Abramenkovs A, Stenerlöw B. Suppression of DNA-dependent protein kinase sensitize cells to radiation without affecting DSB repair. Mutat Res. 2014 Nov;769:1–10. 17. Abramenkovs A, Stenerlöw B. Removal of heat-sensitive clustered damaged DNA sites is independent of double-strand break repair. PloS One. 2018;13(12):e0209594. 18. Jackson SP, Bartek J. The DNA-damage response in human biology and disease. Nature. 2009 Oct;461(7267):1071–8. 19. Botuyan MV, Lee J, Ward IM, Kim JE, Thompson JR, Chen J, et al. Structural Basis for the Methylation State Specific Recognition of Histone H4-K20 by 53BP1 and Crb2 in DNA Repair. Cell. 2006 Dec 29;127(7):1361–73. 20. Feng L, Li N, Li Y, Wang J, Gao M, Wang W, et al. Cell cycle-dependent inhibition of 53BP1 signaling by BRCA1. Cell Discov. 2015 Aug 4;1(1):1–11. 21. Xie A, Puget N, Shim I, Odate S, Jarzyna I, Bassing CH, et al. Control of sister chromatid recombination by histone H2AX. Mol Cell. 2004 Dec 22;16(6):1017–25. 22. Unal E, Arbel-Eden A, Sattler U, Shroff R, Lichten M, Haber JE, et al. DNA damage response pathway uses histone modification to assemble a double-strand break-specific cohesin domain. Mol Cell. 2004 Dec 22;16(6):991– 1002. 23. Franken NAP, Rodermond HM, Stap J, Haveman J, van Bree C. Clonogenic assay of cells in vitro. Nat Protoc. 2006;1(5):2315–9.
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