ESTRO 2024 - Abstract Book
S5345
Radiobiology - Tumour biology
ESTRO 2024
24. Abramenkovs A, Stenerlöw B. Measurement of DNA-Dependent Protein Kinase Phosphorylation Using Flow Cytometry Provides a Reliable Estimate of DNA Repair Capacity. Radiat Res. 2017 Sep;188(6):677–84. 25. Hoglund, E. Blomquist, J. Carlsson, E. DNA damage induced by radiation of different linear energy transfer: initial fragmentation. Int J Radiat Biol. 2000 Jan;76(4):539–47. 26. Abramenkovs A, Hariri M, Spiegelberg D, Nilsson S, Stenerlöw B. Ra-223 induces clustered DNA damage and inhibits cell survival in several prostate cancer cell lines. Transl Oncol. 2022 Dec;26:101543. 27. Solier S, Pommier Y. The Nuclear γ-H2AX Apoptotic Ring: Implications for Cancers and Autoimmune Diseases. Cell Mol Life Sci CMLS. 2014 Jun;71(12):2289–97. 28. Solier S, Pommier Y. The apoptotic ring: A novel entity with phosphorylated histones H2AX and H2B, and activated DNA damage response kinases. Cell Cycle. 2009 Jun 15;8(12):1853–9. 29. Solier S, Sordet O, Kohn KW, Pommier Y. Death Receptor-Induced Activation of the Chk2- and Histone H2AX Associated DNA Damage Response Pathways. Mol Cell Biol. 2009 Jan;29(1):68–82. 30. Solier S, Kohn KW, Scroggins B, Xu W, Trepel J, Neckers L, et al. Heat shock protein 90α (HSP90α), a substrate and chaperone of DNA-PK necessary for the apoptotic response. Proc Natl Acad Sci. 2012 Aug 7;109(32):12866–72. 31. Friedrich J, Seidel C, Ebner R, Kunz-Schughart LA. Spheroid-based drug screen: considerations and practical approach. Nat Protoc. 2009;4(3):309–24. 32. Eilenberger C, Kratz SRA, Rothbauer M, Ehmoser EK, Ertl P, Küpcü S. Optimized alamarBlue assay protocol for drug dose-response determination of 3D tumor spheroids. MethodsX. 2018 Jul 23;5:781–7. 33. Schoenfeld JD, Alexander MS, Waldron TJ, Sibenaller ZA, Spitz DR, Buettner GR, et al. Pharmacological Ascorbate as a Means of Sensitizing Cancer Cells to Radio-Chemotherapy While Protecting Normal Tissue. Semin Radiat Oncol. 2019 Jan;29(1):25–32. 34. Ma E, Chen P, Wilkins HM, Wang T, Swerdlow RH, Chen Q. Pharmacologic ascorbate induces neuroblastoma cell death by hydrogen peroxide mediated DNA damage and reduction in cancer cell glycolysis. Free Radic Biol Med. 2017 Dec 1;113:36–47. 35. Basak D, Uddin MN, Hancock J. The Role of Oxidative Stress and Its Counteractive Utility in Colorectal Cancer (CRC). Cancers. 2020 Nov 11;12(11):3336. 36. Baek MW, Cho HS, Kim SH, Kim WJ, Jung JY. Ascorbic Acid Induces Necrosis in Human Laryngeal Squamous Cell Carcinoma via ROS, PKC, and Calcium Signaling: ASCORBIC ACID INDUCES NECROSIS IN HEP2 CELLS. J Cell Physiol. 2017 Feb;232(2):417–25. 37. Eguchi Y, Shimizu S, Tsujimoto Y. Intracellular ATP levels determine cell death fate by apoptosis or necrosis. Cancer Res. 1997 May 15;57(10):1835–40. 38. Chandra J, Samali A, Orrenius S. Triggering and modulation of apoptosis by oxidative stress. Free Radic Biol Med. 2000 Aug;29(3–4):323–33. 39. Chen Q, Espey MG, Krishna MC, Mitchell JB, Corpe CP, Buettner GR, et al. Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues. Proc Natl Acad Sci. 2005 Sep 20;102(38):13604–9. 40. Artus C, Boujrad H, Bouharrour A, Brunelle MN, Hoos S, Yuste VJ, et al. AIF promotes chromatinolysis and caspase-independent programmed necrosis by interacting with histone H2AX. EMBO J. 2010 May 5;29(9):1585–99. 41. Ding D, Zhang Y, Wang J, Zhang X, Gao Y, Yin L, et al. Induction and inhibition of the pan-nuclear gamma H2AX response in resting human peripheral blood lymphocytes after X-ray irradiation. Cell Death Discov. 2016 Mar 21;2(1):1–10. 42. Cook PJ, Ju BG, Telese F, Wang X, Glass CK, Rosenfeld MG. Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions. Nature. 2009 Apr 2;458(7238):591–6. 43. Meyer B, Voss KO, Tobias F, Jakob B, Durante M, Taucher-Scholz G. Clustered DNA damage induces pan nuclear H2AX phosphorylation mediated by ATM and DNA–PK. Nucleic Acids Res. 2013 Jul;41(12):6109–18. 44. Moeglin E, Desplancq D, Conic S, Oulad-Abdelghani M, Stoessel A, Chiper M, et al. Uniform Widespread Nuclear Phosphorylation of Histone H2AX Is an Indicator of Lethal DNA Replication Stress. Cancers. 2019 Mar 13;11(3).
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