ESTRO 2024 - Abstract Book

S572

Clinical - Breast

ESTRO 2024

References:

1. Singareeka Raghavendra A, Kypriotakis G, Karam-Hage M, Kim S, Jizzini M, Seoudy KS, Robinson JD, Barcenas CH, Cinciripini PM, Tripathy D, Ibrahim NK. The Impact of Treatment for Smoking on Breast Cancer Patients' Survival. Cancers (Basel). 2022 Mar 12;14(6):1464. doi: 10.3390/cancers14061464.

2. Perdyan A, Jassem J. Impact of Tobacco Smoking on Outcomes of Radiotherapy: A Narrative Review. Curr Oncol. 2022 Mar 24;29(4):2284-2300. doi: 10.3390/curroncol29040186.

3. Wong G, Lam E, Karam I, et al. The impact of smoking on adjuvant breast cancer radiation treatment: A systematic review. Cancer Treat Res Commun. 2020;24:100185. doi:10.1016/j.ctarc.2020.100185

4. Taylor C, Correa C, Duane FK, Aznar MC, Anderson SJ, Bergh J, Dodwell D, Ewertz M, Gray R, Jagsi R, Pierce L, Pritchard KI, Swain S, Wang Z, Wang Y, Whelan T, Peto R, McGale P; Early Breast Cancer Trialists’ Collaborative Group. Estimating the Risks of Breast Cancer Radiotherapy: Evidence From Modern Radiation Doses to the Lungs and Heart and From Previous Randomized Trials. J Clin Oncol. 2017 May 20;35(15):1641-1649. doi: 10.1200/JCO.2016.72.0722. Epub 2017 Mar 20. 5. Barnett GC, Wilkinson JS, Moody AM, et al. The Cambridge Breast Intensity-modulated Radiotherapy Trial: patient- and treatment-related factors that influence late toxicity. Clin Oncol (R Coll Radiol). 2011;23(10):662-673. doi:10.1016/j.clon.2011.04.011

1723

Mini-Oral

Breast density histogram analysis: the role of fat in outcome prediction after Breast Radiotherapy

Martina Mori 1 , Alfonso Belardo 1 , Andrei Fodor 2 , Paola Mangili 1 , Gabriele Palazzo 1 , Mariagiulia Ubeira-Gabellini 1 , Roberta Tummineri 2 , Miriam Torrisi 2 , Antonella Del Vecchio 1 , Nadia G Di Muzio 2,3 , Claudio A Fiorino 1 1 IRCCS San Raffaele Scientific Institute, Medical Physics, Milan, Italy. 2 IRCCS San Raffaele Scientific Institute, Radiotherapy, Milan, Italy. 3 Vita&Salute University, Medicine&Surgery, Milan, Italy

Purpose/Objective:

The study aimed to define the role of breast densitometric state before RT in association to local/distant progression and overall survival.

Material/Methods:

A large mono-Institutional cohort (n=1127) of early-stage breast cancer patients was enrolled between 2009-2017, homogeneously treated with tangential fields delivering 40Gy/15fractions to the whole breast. Local progression free survival (LPFS), distant progression free survival (DPFS) and overall-survival (OS) were scored after the end of