ESTRO 2024 - Abstract Book

S770

Clinical - CNS

ESTRO 2024

Results:

The median age was 62 years (Range: 52-79 years), the majority were female (70%), and the median Karnofsky performance score was 90 (range: 70-90). Lung (70%) was the most common primary site of disease. Half (5/10) of the patients were treated with hippocampal-avoidance WBRT and the other with conventional WBRT. At baseline, prior to WBRT, connectome analysis revealed that the central executive network had the most anomalies (mean-12; range: 0-28). Pre and post-WBRT comparison revealed increases in several proportional anomaly frequencies, with the highest increases observed in the limbic network (73%) followed by paralimbic network (50%), medial temporal network (29%), subcortical network (25%), central executive network (11%), language network (9%), and dorsal attention network (4%). The neurocognitive assessment demonstrated a decline (defined as a change of point score in each domain) in learning and memory (67% of patients), attention and speed processing (50% of patients), verbal fluency (33% of patients), fine motor and speed functions (33% of patients), and executive function (100% of patients) in comparison to each patient’s own baseline assessment. Pearson correlation showed a very strong correlation between neurocognitive domain decline and anomaly changes: learning and memory domain with subcortical network [Verbal recall (Pearson coefficient -0.94; p<0.01), Verbal revision (Pearson coefficient -0.89; p=0.01), and Verbal recognition (Pearson coefficient -0.94; p<0.01)] (Figure 2).

Figure 2: Scatter diagram showing the correlation between subcortical network anomaly change and Learning and memory domain score changes